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精子DNA损伤与辅助生殖技术 被引量：4

Sperm DNA damage and assisted reproductive techniques
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摘要 精子DNA损伤与辅助生殖技术(ART)结局密切相关,精子DNA损伤影响到ART中的受精比率、胚细胞发育、妊娠率和子代的健康。同时,精子低温冷冻保存和诸多体外处理技术均能影响精子DNA的完整性。检测精子DNA断裂指标(DFI),采取适当措施获得DNA无损伤或损伤较小的精子,对改善ART结局十分必要。现就精子DNA损伤与ART相关性的研究做一综述。 Sperm DNA damage is closely correlated with the outcome of assisted reproductive tech- niques （ART）, but its mechanism still needs to be thoroughly studied. Sperm DNA damage affects the fertilization, embryo development, pregnancy and the off spring＇s health. Cryopreservation of human sper- matozoa and sperm preparation techniques all influence the integrity of sperm DNA. Accordingly, it is nec- essary to detect the DNA fragmentation index （%DFI） and adopt certain measures to obtain those sperms / with less or no damage. In turn, this can improve the outcome of ART. This article reviews the studies on the relationship of sperm DNA damage and ART.
作者 谭广兴 何映
机构地区 南京中医药大学 江苏省中医院
出处 《生殖医学杂志》 CAS 2007年第5期368-372,共5页 Journal of Reproductive Medicine
关键词 精子 DNA损伤 辅助生殖技术 Sperm DNA damage Assisted reproductive technique
分类号 R321.1 [医药卫生—人体解剖和组织胚胎学]
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参考文献36

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二级参考文献38

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生殖医学杂志
2007年 第5期

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