COX-2及VEGF在乳腺癌中的表达及临床意义

The Expression of Cyclooxygenase-2 and VEGF in Breast Cancer and Its Significance

[目的]探讨环氧化酶2(COX-2)及血管内皮生长因子(VEGF)在乳腺癌中的表达及其临床意义。[方法]应用逆转录聚合酶链反应(RT-PCR),检测了96例乳腺癌患者癌组织及癌旁组织中COX-2和VEGF的表达。[结果]COX-2 mRNA和VEGF mRNA分别在87.50%和83.33%乳腺癌组织中表达,而仅在16.67%和31.25%癌旁组织中表达,癌组织与癌旁组织COX-2 mRNA和VEGF mRNA的表达差异有显著意义。[结论]COX-2 mRNA、VEGF mRNA在乳腺癌组织中明显增高。COX-2的表达同VEGF的表达密切相关。

[Purpose] To investigate the expression of cyclooxygenase-2 （COX-2）, vascular endothelial growth factor （VEGF） in breast cancer and its clinical significance. [Methods ] The expression of COX-2 and VEGF in 96 cases of breast cancer tissues and cancer adjacent tissues were detected by reverse transcription-PCR. [Results] Expression of COX-2 mRNA and VEGF mRNA was 87.50% and 83.33% in breast cancer tissues; 16.67% and 31.25% in cancer adjacent tissues respectively. The expression of COX-2 mRNA and VEGF mRNA was significantly different between cancer tissue and cancers adjacent tissue. [Conclusion] Expression of COX-2 and VEGF mRNA in breast cancer is significantly increased. Expression of COX-2 is closely correlated with expression of VEGF .