埃索美拉唑与莫沙必利联合治疗胃食管反流病疗效观察

The clinical observation of esomeprazole alone and esomeprazole plus mosapride in threapy of GERD.

目的观察单用埃索美拉唑及埃索美拉唑联合莫沙必利治疗胃食管反流病(GERD)的临床疗效。方法60例GERD患者随机分为对照组和联合组,每组30例,对照组单用埃索美拉唑,40mg/天,联合组在埃索美拉唑治疗基础上联用莫沙必利5mg,3次/天,疗程均为4周。治疗前后观察食管内24h pH<4的时间变化及GERD症状评分。结果治疗后对照组食管内24h pH<4时间为(37±18)min,联合组为(21±13)min,联合后对照组症状缓解率为83.3%(25/30),联合组为96.7%(29/30);两组食管内24h pH<4时间及症状积分均低于治疗前(P<0.05),联合组此两项亦明显低于对照组(P<0.05)。结论埃索美拉唑可以降低食管内酸度及有效改善GERD临床症状,从而有效治疗GERD,而埃索美拉唑与莫沙必利联合治疗GERD可以达到更满意的临床效果。

Objective To elucicate the clinical effect of the clinical effect of esomeprazole alone and esomeprazole plusmosapride in threapy of Gastroesophageal reflux disease（GERD）. Methods Sixty patients consented to be randomized to re-ceive either esomeprazole 40 nag q. d. （n = 30, group A） or esomeprazole 40 nag q. d. plus mosapride 5 nag t. i. d （n = 30, group B）for 4 weeks, the score of symptom and twenty-four-hour esophageal pH-metry were conducted at moment of hospitalization andafter 4 weeks. Results The two groups had show a significantly decreased in the mean symptom score and twenty-four-hour e-sophageal pH-metry after 4 weeks,and it was significantly lower in group A than in group B （37± 18 rain vs 21± 13 rain and25/30 vs 29/30,P〈0. 05）. Conclusion A combination of pantoprazole and mosapride is more effective than pantoprazole alonein providing symptomatic relief to patients with GERD.