探讨阿米卡星局部封闭预防阑尾炎伴腹膜炎手术切口感染可行性

Probability of the local infiltration with amikacin for preventing the infection of operative incision after resection of appendicitis with peritonitis

目的探讨阿米卡星局部封闭预防阑尾炎伴腹膜炎手术切口感染效果。方法选用急性阑尾炎伴腹膜炎的病人216例,随机等分为两组。同法切除阑尾,缝合腹膜后,研究组用阿米卡星(0.4 g)均匀浸润注射在手术切口边缘肌层及皮下层内;对照组碘伏擦洗、甲硝唑冲洗切口。同法逐层缝合切口。结果两组病例的年龄、性别、发病时间、术前临床表现、术后病理分型无显著差异(P>0.05),研究组切口感染率显著低于对照组(1.85%vs 9.26%,P<0.05)。结论阿米卡星局部封闭可有效预防阑尾炎伴腹膜炎手术切口感染的发生。

Objective To approach the effect of the local infdtration with amikacin for preventing the infection of operative incision after resection of appendicitis with peritonitis： Methods 216 patients undergoing appendicitis with peritonitis were randomly divided into study group and control group. After the resection of appendix and the saturation of peritoneum with the same method the study group incision were injected amikacin（0. 4 g） through locally infiltrating the muscular coat and subcutis at the side of the incision ;the control group incision were swabbed by iodophors and rinsed by arilin. The incisions were sutured with the same method. Results The age, sex, times of morbidity, peroperative clinical situation, postoperative pathotype were no significantly differences between both groups （P 〉0. 05 ）. But the infection rate of incision in study group was significantly lower than that in the control group （ 1.85% vs 9.26% , P 〈 0. 05 ）. Conclusion The local infiltration with amikacin prevented infection form operative incision after resection of appendicitis with peritonitis.