5-芳甲基-4-叔丁基-2-氨基噻唑的合成与表征

Synthesis and Characterization of 5-Arylmethyl -4Tert-Butylthiazol-2 -Amine

溴化铜在乙醇中溴化4，4-二甲基-1-芳基-3-戊酮，得到α-溴化产物不经分离直接与硫脲环合制得9种2一氨基噻唑类新化合物，收率21．9％～92．9％．目标物2-氨基噻唑类化合物经核磁谱、红外光谱、质谱测定其结构．用单晶X-射线衍射测定了化合物1g．HBr的晶体结构．化合物1g．HBr晶体属单斜晶系，空间群为P2（1）／c，晶胞参数为：a=0．96713（5）nm，b=1．55825（8）nm，C=1．30687（7）nm，Z=4，V=1．66534（15）nm^3，Dc=1．577g／cm^3，F（000）=800，R1=0．0313，ωR2=0．0757，S=1．024．

Acyclic-ketones were brominated by cupric bromide to give α-bromoketones in ethanol solvent. The a-bromoketones were carried out to react with thiourea without additional separation to obtain nine 5-arylmethyl-4-tert-butylthiazol-2-amines with a yield of 21.9 % -92.9%. The structures of the 2-aminothiazoles were confirmed by ^1NMR, IR, MS spectra. The crystal structure of compound lg. HBr was determined by X-ray diffraction analysis. The compound lg. HBr crystal belongs to monoclinic system with space group P2（1）/c and cell parameters： a=0.967 13（5） nm, b=1.55825（8） nm, c=1.30687（7） nm, Z=4, V=1.665 34 （15） nm^3, Dc=1.577 g/cm^3, F（000） =800, R1=0.031 3, ωR2=0.075 7, S=1.024.