拉米夫定联合扶正复肝方治疗慢性乙型肝炎及对拉米夫定耐药的影响研究

Study of Lamivudine combined with Fuzheng-Fugan decoction on chronic type B hepatitis and effect on drug fast

目的观察拉米夫定联合扶正复肝方治疗慢性乙型肝炎的疗效和对拉米夫定耐药的影响。方法将78例慢性乙型肝炎(HBV-DNA阳性)患者,随机分为2组:对照组予拉米夫定治疗,治疗组予拉米夫定加扶正复肝方治疗,分别检测血清肝脏生化指标,HBV-DNA阳性率和对拉米夫定的耐药情况。结果在治疗52周时,治疗组血清丙氨酸氨基转移酶复常率和HBV-DNA阴转率比对照组高,耐药率低。结论拉米夫定加扶正复肝方能有效提高慢性乙型肝炎的疗效,并减少拉米夫定的耐药率。

Objective It is to observe the curative effect of Lamivudine combined with Fuzheng- Fugan decoction on chronic type B hepatitis and effect on drug fast of Lamivudine, Methods 78 cases of patients with chronic type B hepatitis whose HBV - DNA was positive were chosen and randomly divided into 2 groups, Control group was given Lamivudine, and treatment group was added with Fuzheng- Fugan decoction on the treatment above, Then serum liver biochemistry indexes were determined and positive rate of HBV - DNA, drug fast of Lamivudine were observed, Results The rate of normal serum ALT and negative rate of HBV - DNA were higher and the drug fast rate was lower in treatment group than that in control group after treating for 52 weeks. Conclusion Lamivudine combined with Fuzheng- Fugan decoction can effectively enhance the curative effect on chronic type B hepatitis and can low down the drug fast.