3,7,10-三甲基-γ-氨丙基杂氮硅三环衍生物的合成

Synthesis of 3,7,10-trimethyl-γ-aminopropyl silatrane derivatives

目的设计合成新的3,7,10-三甲基-γ-氨丙基杂氮硅三环衍生物。方法以三异丙醇胺和γ-氨丙基三乙氧硅烷为原料,通过硅烷化、酰化、磺酰化、异氰酸酯化等反应合成目标化合物(1、2、3a～3c、4a～4d)。结果与结论合成了9个未见文献报道的新化合物,目标物的结构均经1H-NMR、IR、MS及元素分析确证。

Aim To design and synthesize 3, 7, 10-trimethyl-γ-aminopropyl silatrane derivatives. Methods Triisopropanolamine and γ-aminopropyl triethoxysilane were used as raw materials to obtain nine new target compounds through silylation, acylation, sulfonation, and isocyanation. Results and conclusion Nine new compounds which had not been reported were synthesized. The structures of all the compounds were confirmed by IH-NMR, IR, MS as well as elementary analysis.