古尼拟青霉药理作用研究 1.药物毒性及对中枢神经系统的作用

Study of the Pharamacological Action of Paecilomyces Gunnii Ⅰ.The drug toxicity and effect on central nervous system

本文报道古尼拟青霉毒性实验结果和对中枢神经系统的作用。古尼拟青霉干粉经口LD_(50)大于6g/kg;药液经口、皮下及腹腔LD_(50)均大于30/kg。亚慢性毒性实验大鼠进食含本品干粉1、2、3g/kg/d的饲料3个月,血常规、肝、肾功能及脏器的病理组织学检查无异常。本品对中枢神经系统有镇静、加强戊巴比妥钠作用及镇痛、降温等作用。

The acute and subchronic toxicity experiments of paecilomyces Gunnii in mice and rats are reported.The results showed that in acute experiment, the LD_(50) powder given orally was more than 6g/kg, and the LD_(50) of liquids by peroral, hypodermatic and intraperitoneal ways were more than 30g/kg.In the subchronic toxicity experiment, the rats were fed the diet containing paecilomyces gunnii 1, 2, 3g/kg/day respectively for 3 months, and the blood findings, liver and kidney functions and pathological section of visera were all normal.The results suggest that this drug has effects of sedation, analgesia and hypothermy.