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古尼拟青霉药理作用研究 1.药物毒性及对中枢神经系统的作用 被引量:20

Study of the Pharamacological Action of Paecilomyces Gunnii Ⅰ.The drug toxicity and effect on central nervous system
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摘要 本文报道古尼拟青霉毒性实验结果和对中枢神经系统的作用。古尼拟青霉干粉经口LD_(50)大于6g/kg;药液经口、皮下及腹腔LD_(50)均大于30/kg。亚慢性毒性实验大鼠进食含本品干粉1、2、3g/kg/d的饲料3个月,血常规、肝、肾功能及脏器的病理组织学检查无异常。本品对中枢神经系统有镇静、加强戊巴比妥钠作用及镇痛、降温等作用。 The acute and subchronic toxicity experiments of paecilomyces Gunnii in mice and rats are reported.The results showed that in acute experiment, the LD_(50) powder given orally was more than 6g/kg, and the LD_(50) of liquids by peroral, hypodermatic and intraperitoneal ways were more than 30g/kg.In the subchronic toxicity experiment, the rats were fed the diet containing paecilomyces gunnii 1, 2, 3g/kg/day respectively for 3 months, and the blood findings, liver and kidney functions and pathological section of visera were all normal.The results suggest that this drug has effects of sedation, analgesia and hypothermy.
出处 《贵阳医学院学报》 CAS 1990年第1期25-28,共4页 Journal of Guiyang Medical College
关键词 古尼拟青霉 药理作用 中枢神经系统 paecilomyces gunnii LD_(50) sedatives analgesics mice rats
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