原发性甲状腺鳞状细胞癌临床病理分析

Clinical and pathological analysis in primary squamous cell carcinoma of thyroid

目的:探讨原发性甲状腺鳞状细胞癌的临床病理特点、诊断及鉴别诊断。方法:分析5例原发性甲状腺鳞状细胞癌的临床、病理及随访资料,对标本进行HE及免疫组织化学染色并观察分析。结果:原发性甲状腺鳞状细胞癌的病理分级多属鳞癌I^II级;免疫组织化学染色:CD44V6、CK在原发灶及淋巴结转移灶内肿瘤细胞均呈强阳性表达,而甲状腺球蛋白(TG)呈弱阳性表达。结论:原发性甲状腺鳞状细胞癌恶性程度高。CD44V6的高表达与原发性甲状腺鳞状细胞癌的侵袭转移密切相关,免疫组织化学TG标记对鉴别诊断有帮助。

Objective： To study the clinicopathological characteristics, the diagnosis and differential diagnosis of primary squamous cell carcinoma of thyroid （SCCT）, Methods： The clinical, pathological and following-up information were retrospectively reviewed in 5 cases of the tumor, The pathological characteristics were studied with HE and immunohistochemical stains. Results： The differentiation degree of SCCT was degree Ⅰ-Ⅱ Immunohistochemical study showed that CD44V6 and CK were strongly expressed in primary area and metastatic area of SCCT, TG was weakly expressed. Conclusions： SCCT is a rare type of thyroid carcinoma, but highly aggressive, The overexpression of CD44V6 is closely relate to invasion and metastasis in SCCT. Immunohistochemical stains for TG is helpful in confirming the diagnosis