甲巯丙脯酸治疗高血压病的临床研究

Clinical Studies of Essential Hypertension Treated with Captopril

本文报告甲巯丙脯酸治疗36例高血压病4周时总有效率86.1%。首次服药后15min降压,2h最明显,持续10h以上。用药后血浆肾素活性增高,血浆血管紧张素Ⅱ,醛固酮浓度及血管紧张素转换酶活性降低,并都在首次服药后2h变化最明显。用药4周时血浆心房利钠因子浓度下降。

The acute and short-term effects of captopril were studied in 36 patients with essential hypertension. After ingestion of the first dose 25 mg of captopril, blood pressure (BP) fell at 15 min, the maximal fall in BP was observed at 2h and the duration of the action exceeded 10 hours. After administration of daily doses ≤50 mg of captopril for 4 weeks, the total response rate of all patients was 86.1% and rose to 97.2% when the noneffective patients were combined with once-daily 25 mg of hydrochlorothiazide for 1 week. The patients with mill and moderate or all phases of essential hypertension were effective. The acute fall in BP was significantly correlated with the short-term fall in BP. Plasma renin activity (PRA) was increased, and plasma angiotensin II (ATII), aldosterone concentration (PAC) and angiotensin converting enzyme activity (ACE) were decreased during treatment. These changes at 2 h were maximal after the first dose. Plasma atrial natriuretic factor concentration (ANF) was markedly decreased at the end of 4 weeks.