安非他酮与文拉法辛治疗抑郁症对照研究

Comparative study between bupropion and venlafaxin in treatment of depression

目的:比较安非他酮与文拉法辛治疗抑郁症的临床疗效和安全性。方法:将90例抑郁症患者随机分为安非他酮组(45例)和文拉法辛组(45例),疗程6周。采用汉密尔顿抑郁量表(HAMD)、治疗中出现的症状量表(TESS)评定疗效和安全性。结果:文拉法辛组治疗1周后起效;疗程结束时,两组疗效和HAMD评分差异无显著性,不良反应少而轻。结论:安非他酮与文拉法辛治疗抑郁症疗效相当,文拉法辛起效较快,安非他酮作用温和,依从性好。

Objective：To compare the clinical efficacy and safety of bupropion and venlafaxin in the treatment of depression. Method： Ninety patients with depression were randomly divided into bupropion group or venlafaxin group and then received treatments for 6 weeks. Hamilton depressive scale （HAMD） and treatment emergant sympton scale （TESS） were used to evaluate the efficacy and safety respectively. Results：The effectiveness was emerged at the end of 1 st week after treatment in the patients of venlafaxin group, At the end of 6th week, there were no significant differences in the efficacy and scores of HAMD between two groups. The side effects of both groups were few and slighdy. Conclusion： Bupropion and venlafaxin are both effective in the treatment of depressive episode. Bupropion has fewer side effects and better compliance.