红景天多糖的提取纯化及其分散片制备工艺

Method of preparing the Rhodiola sachalinensis dispersible

目的:筛选红景天分散片处方及制备工艺。方法:采用均匀设计优选红景天多糖提取工艺;通过对ZTC1+1吸附法,壳聚糖吸附法,醇沉法的比较,选出最佳精制工艺;应用正交试验设计筛选分散片处方。结果:红景天多糖最佳提取工艺为:提取温度为95℃,用12倍的水,提取3次,每次2.5 h。采用ZTC1+1吸附澄清法精制。以8%低取代羟丙基纤维素(L-HPC)、8%羧甲基淀粉钠(CMS-Na)、5%聚乙烯吡咯烷酮(PVPK-30)、6%微晶纤维素(MCC)为崩解剂,内外比例为25∶75,20%乙醇溶液为润湿剂,采用湿法制粒压片。结论:制得的红景天分散片崩解时限符合《中国药典》(2005年版)规定。

Objective： To choose recipe and preparetion of the Rhodiola sachalinensis dispersible. Methotis： Herb extraction method of the polysaccharide was determined by Uniform design. Through the compare of the ethanol extraction, ZTC1 ＋ 1 adsorbing purification, and chitosan adsorbing purification, choose the best extraction method. The choice of recipe was studied by orthogonal design. Results： The best extraction of the polysaccharide of the Rhodiola sachalinensis A. Bor. was： when the temperature of extraction was 95℃ ,the solvent was water and the material was 12：1 ,extract 3 times, each time was 2.5 h. ZTC1 ＋ 1 adsorbing purification was used to extract Rhodioloside. The Rhodiola sachalinensis dispersible tablet was prepared by making wet grain compression. The disintegrants was L-HPC, CMS - Na, PVPP and MCC . And inverse proportion was 8% ,8%, 5% ,6%, distributed as 25： 75. 20% ethanol was moistening agents. Conclusion： The prepared tablets＇ test of disintegration was conducted based on Chinese Pharmacopoeia（2005）.