传染性单核细胞增多症患儿T细胞亚群变化及临床意义

Change of T cell subsets in children with infectious mononucleosis and its clinical meanings

目的:通过检测传染性单核细胞增多症(IM)患儿外周血T细胞亚群,探讨其免疫功能与疾病的关系。早期了解疾病的发生并加以干预以减少不良的预后。方法:采用流式细胞仪对观察组18例IM患儿进行T细胞亚群测定,同时随机抽取20例健康儿童作为对照组。另外对观察组18例患儿中的10例进行治疗2周后T细胞亚群的测定。结果:观察组与对照组CD4,CD4/CD8均明显下降(P<0.001),CD8明显升高(P<0.001)。观察组的10例治疗2周后T细胞亚群的测定值与入院时比较有显著差异(P<0.001)。结论:EB病毒感染引起机体免疫功能改变是IM发病的关键,早期诊断治疗、长期随访都有积极的意义。

Objective： To measure the expression level of T lymphocyte subsets in peripheral blood in order to investigate the change of immunity in children with infectious mononucleosis （IM）. Methods： T lymphocyte subsets in peripheral blood were measured by cytometry in 18 cases with IM who were treated in the department of pediatrics of the third affiliated hospital of Suzhou university from 2005.1 - 2007.2. They were compared with 20 normal children . Additionally we measure the expression level of T lymphocyte subsets of 10 cases from 18 cases of IM receiving treatment two weeks later in order to explore the dynamic change. Results： The IM patients showed an obvious decrease in percentage of CD4 cells as well as a ratio of CD4/CD8 （ P 〈 0.01 ）, but obvious elevation of CD3, CD8 cells （ P 〈 0.01 ） . The level of T lymphocyte subsets had marked difference between 18 IM and 10 cases from 18 cases IM being treatment two weeks later （ P 〈 0.01 ）. Conclusion： The key of reduction in IM was the change of immunity function after infected by EB virus. It is important to diagnose and treat more earlier, treat and observe long-term.