摘要
Dialdehyde starch nanoparticles (DASNP) were prepared by the redox reaction of NaIO4 and starch in water-in-oil microemulsion. IR spectrum showed that DASNP had aldehyde groups, and quantitative alkali consumption showed that its dialdehyde content was about (50±5)%. The average diameter of DASNP determined by SEM was about 100 nm. TGA-DTA showed that its thermal stability was better than starch nanoparticle (StNP) and dialdehyde starch (DAS). Its low biological toxicity was detected by cell experiment. Also the best mass ratio of doxorubicin (DOX) to combined DASNP detected by UV-VIS was 15 : 1, and the product was effective for controlled release of DOX. The cell experiment showed that the drug-carrier particle (DOX-DASNP) can release DOX for a long time and strengthened the effect of the anticancer drug. This work demonstrates that the DASNP, which has good thermal stability, small particle size, low biological toxicity, and slowly anticancer drug-releasing to strengthen drug effect, is a potentially useful carrier for anticancer drug.
Dialdehyde starch nanoparticles （DASNP） were prepared by the redox reaction of NalO4 and starch in water-in-oil microemulsion. IR spectrum showed that DASNP had aldehyde groups, and quantitative alkali consumption showed that its dialdehyde content was about （50~5）%. The average diameter of DASNP determined by SEM was about 100 nm. TGA-DTA showed that its thermal stability was better than starch nanoparticle （StNP） and dialdehyde starch （DAS）. Its low biological toxicity was detected by cell experiment. Also the best mass ratio of doxorubicin （DGX） to combined DASNP detected by UV-VlS was 15 ： 1, and the product was effective for controlled release of DGX. The cell experiment showed that the drug-carrier particle （DGX-DASNP） can release DGX for a long time and strengthened the effect of the anticancer drug. This work demonstrates that the DASNP, which has good thermal stability, small particle size, low biological toxicity, and slowly anticancer drug-releasing to strengthen drug effect, is a potentially useful carrier for anticancer drug.
基金
Supported by the Emphases Program for Science and Technology of Hunan Province (Grant No. 03NKY1001)
985 Foundation Grant from Hunan University
关键词
乳腺癌细胞
毫微粒
药物依赖性
阿霉素
dialdehyde starch, nanoparticle, mammary cancer cell, drug carrier, doxorubicin
