生长激素对人体衰老影响的初步研究

A preliminary study on the influence of growth hormone on the aging process

目的探讨生长激素对人体衰老的影响。方法１２名自愿参加试验研究的健康老年人皮下注射人类生长激素（ｒ－ｈｕｍａｎｇｒｏｗｔｈｈｏｒｍｏｎｅ，ｒ－ｈＧＨ），剂量为０．０８Ｕ／ｋｇ，每周３次，共用６个月。结果胰岛素样生长因子（ｉｎｓｕｌｉｎ－ｌｉｋｅｇｒｏｗｔｈｆａｃｔｏｒ－１，ＩＧＦ－１）水平注射前均值为７６２±１７８Ｕ／Ｌ，注射３个月后升高为１０６２±１２７Ｕ／Ｌ，差异有显著性（Ｐ＜０．０１）。但注射６个月后，下降为６９７±１２４Ｕ／Ｌ，与３个月相比，差异亦有显著性（Ｐ＜０．０１）。ＩＧＦ－１下降原因不明。采用双能Ｘ线吸收仪（ｄｕａｌｅｎｅｒｇｙＸ－ｒａｙａｂｓｏｒｐｔｉｏｍｅｔｒｙ，ＤＥＸＡ）测定脂肪和精肉，试验前后分别为１４５５９±４１８２ｇ及１３７０９±３３２５ｇ和４９６８３±２８０及５０３１７±２９３５ｇ，但差异无显著性；骨密度在试验前后变化不显著。结论所有受试者试后均保持健康，除２例６个月血糖稍升高（分别从５．０８上升至７．８９ｍｍｏｌ／Ｌ和５．６７上升至８．２４ｍｍｏｌ／Ｌ）外，无明显副作用，对应用ｒ－ｈＧＨ延迟生理衰老的利弊尚需做更多病例观察。

Objective This protocol was designed to investigate the influence of growth hormone (GH) on the aging process. Methods Twelve healthy old volunteers were given GH 0 08U/kg subcutaneously 3 times per week for 6 months. The value of insulin like growth factor 1(IGF 1) was determined with radioimmunoassay. The lean body mass and body fat were measured with dual energy X ray absorptiometry (DEXA). Results The mean value of IGF 1 was 762±178U/L and 1062±127U/L prior to and 3 months after the treatment respectively. There was significant difference between the two values ( P <0 01). However, at the end of 6 months the value declined to 697±124 U/L ; the cause is unknown. There is a tendency of increase in lean body mass and decrease in body fat( P >0 05) as shown by DEXA. There is generally no significant change in bone density but with a little increase in L2 4. Conclusions These results suggest that GH play a role in increasing the lean body mass and decreasing body fat.