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地尔硫■控释片与戊四硝酯片对老年冠心病心绞痛与收缩时间间期的疗效比较

Comparison of diltiazem hydrochloride controlled release tablet and pentaerithrityl tetranitrate tablet on angina pectoris and systolic time intervals in elderly coronary disease
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摘要 目的:比较盐酸地尔硫控释片(下简称地片)与戊四硝酯(下简称硝片)治疗老年冠心病心绞痛的疗效及对收缩时间间期(STI)的影响。方法:冠心病心绞痛病人45例(男性29例,女性16例;年龄64±s4a)以随机、双盲、交叉对照法分别先后采用地片30~90mg,po,tid,加外观似硝片的安慰剂(淀粉)1~3片,po,tid,共4wk,为治疗组;或以硝片10~30mg,po,tid,加外观似地片的安慰剂1~3片,po,tid,共4wk,为对照组。2组于4wk疗程结束时,各给2种安慰剂1wk,待体内药物排尽然后2组交叉服药4wk。结果:地片组与硝片组比较,心绞痛症状疗效分别为96%对42%(P<0.01);心电图疗效分别为44%对29%(P>0.05);治疗组有显著降低高血压病人的舒张压及PEP/LVET比值的作用。结论:地片对心绞痛症状疗效、对原有高血压和STI不正常者疗效优于硝片。 AIM: To campare the diltiazem hydrochloride (Dil) and pentaerithrityl tetranitrate (PT) on coronary disease with angina pectoris and systolic time intervals (STI) in elderly. METHODS: Coronary disease with angina pectoris 45 patients (M 29, F 16; age 64±s 4 a) by randomized, double-blind and cross-over tests with Dil 30-90 mg(30 mg/Tab), po, tid, and placebo (starch) 1-3 tablets, po, tid×4 wk. PT 10-30 mg(10 mg/Tab) po, tid, and placebo (starch) 1-3 tablets, po, tid×4 wk. Then cross-over ×4 wk. RESULTS: The clinical symptom and ECG effective rate were 96% vs 44%(P<0.01), and 44% vs 29%(P>0.05), respectively Dil vs PT. Dil reduced blood pressure in patients with hypertension, especially for diastolic pressure (P<0.05), in addition, Del reduced PEP/LVET in coexist hypertension patients with raised PEP/LVET. CONCLUSION: Effect of Dil is better than PT. 1Jinshan County Central Hospital, Shanghai 201500
出处 《新药与临床》 CSCD 北大核心 1997年第3期136-138,共3页
关键词 地尔硫ZHUO 戊四硝酯 心绞痛 心脏收缩期 老年人 diltiazem pentaerythritol tetranitrate coronary disease angina pectoris systole delayed-action preparations aged electrocardiography
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