赖氨匹林的解热、镇痛和抗炎作用

Anti-inflammatory, analgesic and antipyretic activities of lysine-aspirin

目的：应用大鼠及小鼠研究赖氨匹林的抗炎、镇痛及解热作用。方法：用大鼠足跖肿胀研究抗炎作用，用小鼠醋酸扭体法及热板法测定镇痛作用，用鲜酵母法测定解热作用。结果：赖氨匹林对大鼠足跖肿胀有明显抑制作用，最大抑制率为８０％（Ｐ＜０．０１）。小鼠醋酸扭体法测得镇痛ＥＤ５０＝７２±２３ｍｇ／ｋｇ，对鲜酵母致大鼠体温升高有明显抑制作用。小鼠半数致胃溃疡剂量ＵＤ５０＝０．１８±０．０６ｍｍｏｌ／ｋｇ，是阿司匹林的２．４倍。结论：赖氨匹林具有和阿司匹林相当的解热、镇痛和抗炎作用，而对胃肠道的毒副作用比阿司匹林小。

AIM : To study the anti-inflammatory, analgesic and antipyretic effects of lysine-aspirin (LSA) with rats and mice. METHODS: The anti-inflammatory effect was studied by rat paw edema, the analgesic effect by mouse acetic acid writhing and hot-plate methods and the antipyretic activity by fresh yeast method. RESULTS: LSA inhibited rat paw edema. The maximum inhibitory rate was up to 80%(P<0.01). LSA inhibited both the primary and secondary inflammatory reactions and adjuvant arthritis in rats. The analgesic ED 50 in mice was 72±23 mg/kg measured by the method of acetic acid writhing. LSA had antipyretic effect on fever induced by fresh yeast in rats. The UD 50 of LSA in mice was 0.18±0.06 mmol / kg which was 2.4 folds of that of aspirin in moles. CONCLUSION: LSA had similar anti-inflammatory, analgesic and antipyretic effects to aspirin, whereas it had much less gastrointestinal lessions than aspirin in comparable doses.