特布他林加赛庚啶与氨茶碱治疗婴儿气喘和咳嗽的比较

Terbutaline plus cyproheptadine vs aminophylline in treating asthma and cough in infants

目的：探讨特布他林加赛庚啶对婴儿气喘和咳嗽的疗效，并与氨茶碱作比较。方法：治疗组３１例（男性２１例，女性１０例，年龄１５±ｓ６ｍｏ）采用特布他林０．０６５ｍｇ／（ｋｇ·ｄ），赛庚啶０．２５ｍｇ／（ｋｇ·ｄ），均分为３次口服。对照组２８例（男性１６例，女性１２例，年龄１６±６ｍｏ）用氨茶碱３～５ｍｇ／（ｋｇ·ｄ），分３次口服。２组综合治疗（地塞米松、镇咳药、抗生素、吸氧）大致相仿。结果：２组总显效率分别是５５％和２５％，治疗组止咳平喘作用显著优于对照组（Ｐ＜０．０５）。结论：特布他林加赛庚啶治疗婴儿气喘和咳嗽的安全性强、疗效较好。

AIM: To compare the efficacy of terbutaline plus cyproheptadine vs aminophylline in treating asthma and cough. METHODS: Besides the similar conventional treatments (dexamethasone, antitussive agents, antibiotics and oxygen), thirty-one patients (M 21, F 10, age 15±s 6 mo) received terbutaline (Ter) 0.065 mg/(kg·d) and cyproheptadine (Hep) 0.25 mg/(kg·d), po, tid; twenty-eight patients (M 16, F 12, age 16±6 mo) received aminophylline (Ami) 3-5 mg/(kg·d), po, tid. RESULTS: The excellent response rate in Ter+Hep and Ami groups were 55% and 25%, respectively and the effect in relieving the cough and asthma in Ter+Hep group was superior to that in the Ami group (P<0.05). CONCLUSION: Terbutaline plus cyproheptadine is safe and efficient for treatment of asthma and cough in infants.