高乌甲素用于腹部手术后镇痛的双盲试验

New Drugs and Clinical Remedies 1997 Mar; 16(2):75-76 Lappaconitine for postoperative pain: a double-blind study

目的：验证高乌甲素氢溴酸盐的临床镇痛效果。方法：按双盲试验对８０例硬膜外麻醉下腹部手术的病人于术终后出现高度疼痛时随机分组并分别ｉｍ高乌甲素氢溴酸盐４ｍｇ，８ｍｇ和氯化钠１８ｍｇ（安慰剂）。观察并记录其镇痛效果，记录各项物理检查与生化检查的改变。结果：２个用药组有效加稍有效率皆占８１％，与安慰剂组（４１％）相比Ｐ＜０．０１，但２个用药组的显效率皆为０。在镇痛的起效与维持时间上，８ｍｇ组优于４ｍｇ组。用药后未见有不良反应。结论：高乌甲素氢溴酸盐用于腹部手术后镇痛，强度尚嫌不足，适用于轻和中度的慢性疼痛。

AIM: To evaluate the clinical analgesic effect of lappaconitine. METHODS: The 80 patients with intense pain after abdominal operations were divided into 3 groups in a double-blind method. Group I and group II were injected im lappaconitine 4 mg and 8 mg, respectively, while group III was injected im placebo (NaCl 18 mg). RESULTS: The total effective rates of both group I and II were 81%, comparing with that in the placebo group (41%), P<0.01, but no one whose pain was completely relieved. The onset time and sustained time of analgesia were better in group II than that in group I. No obvious adverse reactions were found. CONCLUSION: Lappaconitine has a certain analgesic effect, but its analgesic potency is not enough.