麦滋林-s加雷尼替丁治疗消化性溃疡

New Drugs and Clinical Remedies 1997 Mar; 16(2):77-78 Effect of Marzulene-s combined with ranitidine in treating peptic ulcer

目的：观察麦滋林－ｓ加雷尼替丁治疗消化性溃疡的疗效。方法：经胃镜确诊的消化性溃疡８７例，随机分为治疗组（男性４０例，女性７例，年龄３８±ｓ１４ａ）餐前冲服麦滋林－ｓ０．６７ｇ，ｔｉｄ，加雷尼替丁胶囊１５０ｍｇ，ｂｉｄ；对照组（男性３７例，女性３例，年龄３８±１３ａ）单用雷尼替丁１５０ｍｇ，ｐｏ，ｂｉｄ。疗程均为４～６ｗｋ。结果：消化性溃疡治疗４ｗｋ和６ｗｋ的愈合率，治疗组是６２％和９６％，对照组是３０％和８５％，２组４ｗｋ和６ｗｋ的愈合率相比Ｐ＜０．０５和Ｐ＞０．０５。症状消失时间依次为８±３ｄ和１３±３ｄ，Ｐ＜０．０１。治疗后９～１２ｍｏ溃疡复发率依次为６％和１５％。结论：麦滋林－ｓ加雷尼替丁治疗消化性溃疡较单用雷尼替丁的效果好。

AIM: To evaluate the effect of Marzulene-s plus ranitidine in the treatment of peptic ulcer. METHODS: The 87 patients with peptic ulcer diagnosed with gastroscope were divided into 2 groups at random. The treatment group (M 40, F 7, age 38±s 14 a) were given Marzulene-s 0.67 g, po, tid before meal and ranitidine 150 mg po bid. The control group (M 37, F 3, age 38±13 a) took only ranitidine 150 mg, bid. The therapeutic course were 4-6 wk. RESULTS: The cure rates of the 2 groups were 62% and 30% after 4 treatment wk, and 96% and 85% after 6 treatment wk, respectively. The duration of disappearance of symptom were 8±3 d and 13±3 d, respectively. The recurrent rates of 9-12 mo after the treatment completion were 6% and 15%, respectively. Adverse reactions were mild. CONCLUSION: the combination of Marzulene-s with ranitidine was more effective than ranitidine alone in the treatment of peptic ulcer.