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巴曲抗栓酶与右旋糖酐治疗急性脑栓塞的比较 被引量:9

New Drugs and Clinical Remedies 1997 Mar; 16(2):88-89 Batroxobin (DF-521) vs dextran in treatment of acute cerebral embolism
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摘要 目的:探讨巴曲抗栓酶治疗急性脑栓塞的疗效。方法:经CT诊断的急性脑栓塞病人48例,随机分为巴曲抗栓酶组(治疗组)和右旋糖酐组(对照组)各24例。治疗组按巴曲抗栓酶剂量分为10BU,iv,drip,qd×3d和5BU,ivdrip,qd×7d2个亚组,按开始用药时间分为24h内和72h内2个亚组。对照组用右旋糖酐-40葡萄糖液500mL/d,ivdrip×10d。结果:治疗组在治疗1wk末、1mo末神经功能缺损评分的平均减少分数(MDS)比对照组增加,但仅在1wk末时有显著性差异;剂量不同在疗效上无显著差异,而开始治疗时间24h内优于72h内治疗组。未见不良反应。结论:巴曲抗栓酶治疗急性脑栓塞疗效较好,但宜早期使用,疗程可延长。 AIM: To observe the clinical effects of batroxobin (DF_521) in the treatment of acute cerebral embolism. METHODS: Forty-eight patients with acute cerebral embolism, confirmed by CT scan, were randomly divided into treatment group and control group (each 24 cases). The treatment group was divided into two subgroups according to batroxobin (DF-521) doses: 10 BU iv drip qd for 3 d and 5 BU iv drip qd for 7 d; divided into two subgroups according to the starting therapy within 24 h and 72 h after onset. Control group received dextran-40 in glucose 500 mL, iv drip, qd for 10 d. RESULTS: There was a trend in favor of the batroxobin (DF-521) group in the mean decreased scores (MDS) of neurologic deficits by repeated neurologic examinations, but the differences between the two groups showed significance at the end of 1 wk, and no significance at the end of one month. Clinical improvement appeared in patients of starting therapy within 24 h after onset, but there was no differences between the two subgroups of different doses. No adverse reaction were found. CONCLUSION: The early start and longer therapy with batroxobin (DF-521) are recommended.
出处 《新药与临床》 CSCD 北大核心 1997年第2期88-89,共2页
关键词 巴曲抗栓酶 右旋糖酐类 脑栓塞 药物疗法 batroxobin (DF-521) dextrans cerebral embolism and thrombosis neurologic examination
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参考文献4

  • 1吴萍嘉,新药与临床,1996年,15卷,26页
  • 2匡培根,临床神经病学杂志,1995年,8卷,329页
  • 3吴为平,中风与神经疾病杂志,1995年,12卷,73页
  • 4孟家眉,中华神经精神科杂志,1988年,21卷,57页

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