肝前型门静脉高压大鼠门体分流及循环动力学的实验研究

Portal systemic shunting and hemodynamics of prehepatic portal hypertensive rat models

作者使用放射性微球技术，观察了３１只大鼠不同程度门静脉缩窄后血流动力状态及门体分流量和门静脉压力之间的关系。结果显示，肝前型门静脉高压大鼠存在显著的高循环动力状态：心输出量及心脏指数明显升高，平均动脉压降低，伴有外周血管阻力下降；内脏血流量增加，血管阻力下降；门体分流量明显增加，并与门静脉压力的升高两者之间存在明显正相关Ｙ＝２６．１４＋５．３２Ｘ（ｒ＝０．７６，Ｐ＜０．００１）。作者认为，全身及内脏血流增加是维持实验动物门静脉高压状态的主要因素。

Hemodynamics and relationship between portal systemic shunting and portal pressure were measured by radioactive microsphere techniques in 31 rats after various degree portal vein constriction.Prominent hyperdynamic state was present in prehepatic portal hypertensive rats models. Both cardiac output and index were increased, the mean arterial pressure and pripheral resistance were reduced significantly. The total splanchnic blood flow was increased but splanchnic resistance reduced remarkably. Portal systemic shunting flow was higher. There was a significant positive correlation between them, Y =26.14+5 32X( r =0 76, P <0 001).For this reason, elevated systemic and portal venous flow provided main impetus for maintaining portal hypertension.