摘要
目的探讨冠心病患者妊娠相关蛋白-A(PAPP-A)与冠状动脉病变支数的关系。方法42例冠心病患者,分为急性心肌梗死(AMI)组12例,不稳定型心绞痛(UAP)组15例,稳定型心绞痛(SAP)组15例,均行冠状动脉造影(CAG)确诊,16例CAG结果正常者为对照组。采用酶联免疫吸附法(ELISA)测定其PAPP-A水平,分析与冠状动脉病变支数的关系。结果PAPP-A在AMI和UAP组中水平明显高于SAP和对照组(P<0.01),但在AMI组与UAP组,SAP和对照组之间,单支、双支、三支病变组之间差异无统计学意义(P>0.05)。结论PAPP-A参与动脉硬化粥样斑块的发生发展过程,可作为预测斑块稳定性的标志物。
Objectlve To investigate the relationship between pregnancy-associated plasma protein A （PAPP-A） and the stenosis number coronary lesions in patients with coronary heart disease （CHD）. Method 42 patients with CHD were divided into the acute myocardial infarction（AMI）group（n=12）,the unstable angina pectoris（UAP） group（n=15） and the stable angina pectoris（SAP） group（n=15）, by coronary angiography （CAG）, 16 normal subjects without CHD diagnosed by CAG served as the control group. The serum level of PAPP-A by enzyme linked immunosorbent assay （ELISA）.The relationships between PAPP-A and the stenosis number of coronary artery were analyzed. Result The mean level of serum PAPP-A was obviously higher in the AMI and UAP group than in the SAP and control group（P〈0.01）, but there were no significant differences in AMI group and UAP group,in SAP group and in control group ,among the single vessel,the double group and three vessel lesion group （P〉0.05）. Conclusion PAPP-A can play role in the occurance and development of atheromatous plaque and probably act as one of the biomarkers of vulnerable plaques.
基金
河南省自然科学基金资助项目(0511041900)
关键词
冠心病
妊娠相关蛋白-A
冠状动脉
Coronary heart disease
Pregnancy-associated plasma protein A
Coronary artery
