摘要
用含有日本脑炎病毒（ＪＥＶ）结构蛋白ＰｒＭ、Ｅ和非结构蛋白ＮＳ１、ＮＳ２Ａ基因的重组痘苗病毒Ｊ３免疫家兔，能较快地诱生抗ＪＥＶ抗体，其滴度可随免疫次数的增加和免疫时间的延长而增高。此抗血清可被动保护不同毒株ＪＥＶ的致死性攻击，该保护作用与其中抗体和血凝抑制抗体有关。
Immunization of rabbits with a recombinant vaccinia virus J 3 containing PrM,E,NS1, NS2A genes of japanese encephalitis virus(JEV) could produce rapidly specific antisera against JEV and the titres of antibodies increased with immunization times. Passive protective assay demonstrated that the antisera had an excellent protective efficacy in mice challenged with three different JEV strains.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1997年第2期90-92,共3页
Immunological Journal
关键词
乙型脑炎
重组痘苗病毒J3
免疫原性
Recombinant vaccinia virus J 3, Japanese encephalitis virus, Immunogenicity, Passive protection
