频发室性早搏患儿尿儿茶酚胺测定及临床意义

Determination of urinary catecholamine and the clinical siginicance in child patients with frequent ventricular extrasystoles

目的探讨频发性室性早搏患儿尿中儿茶酚胺的含量及其临床意义。方法频发性重性早搏患儿30例，男17例，女13例;30例健康儿童为对照组、男14例，女16例，24h尿儿茶酚胺测定采用高效液相色谱法。对测定结果进行统计学分析。结果30例频发性定性早搏用儿与30例健康儿童24h尿儿茶酚胺水平分别为543.51±137.56mmol／24h和229.96±93.09mmol／24h，二者相比有极显著性差异（t=10.34，P<0.001）。两组中分别有26例（86.7％）和2例（67％）尿地茶酚胺含量升高。17例心肌炎并早搏与13例单纯性早搏患儿24h尿儿茶酚胺水平分别为553.14±131.13mmol／24h和531.01±151.73mmol／24h，二者相比无显著性差异（P＞005）。早搏次数≥10次／min和＜10次／min的14例和16例患儿24h尿儿茶酚胶水平分别为597.26±128.73mmol／24h和496.48±134.18mmol／24h，二者相比有显著性差异（t=2.09，P＜0.05）.结论室性早搏患儿尿中儿茶酚胺含量明显高于正常儿童。尿中几茶酚腹水平与史性早搏次数呈正相关，而与早搏的原发病无关。

Objectives: To search for the content of urinary catecholamine (CA)and the clinical significance in child patients with frequent ventricular extrasystoles.Methods: There were 30 cases of frequent ventricular extrasystoles (17 males and 13 females) and 30 normal children (14 males and 16 femalcs) in the control group. The 24-hour urinary CA was determined by high-performance liquid chromatography (HPLC),The statistical analysis of detcrmination rcsults was carried out.Rfsults:The levels of 24-hour urinary CA in child patients with frequent ventricular extrasystoles and normal children were 543. 51±137. 56 mmol /24h and 229. 96 ± 93. 09 mmol/ 24h respectively. There was obvlous difference between the two groups(t=10. 34, P<0. 001). In the two groups. there were respectively 26 (86. 7%) and 2 caacs (6.7%) that the levels of 24-hour urinary CA were Increased. The 24-h0ur urinary CA lcvels in 17 cases of extrasystole with myocarditis and 13 cases of simple extrasystole were 553. 14 ±131. 13 mmol/24h and 531. 01±151. 73 mmol/24h (P>0. 05). The levels of 24-hour urinary CA in 14 cases with extrasystole ≥10 times /min and 16 cases with extrasytole < 10 times / min were 597. 26±128. 73 mmol/24h and 496. 48±134. 18 mmol/24h respetively. There was obvious difference between the two groups (t= 2.09, P＜0.05) Conclusions: The 24-hour urinary CA level in the child patients with ventrlcular extrasystoles is obviously increased ，and it has posltlve correlation with the frequency of extrasystoies and has not correlation with the primary diseases.