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腹膜透析患者头孢类抗生素脑病2例 被引量:3

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摘要 患者1,男,66岁,因“发热、腹痛7天,意识模糊2天”急诊入院。患者3年前确诊为多发性骨髓瘤、慢性肾功能不全(尿毒症期),行间断化疗及维持性腹膜透析治疗,病情缓解。7天前患者无明显诱因出现发热、腹痛、引流出腹透液混浊,在当地医院输注头孢吡肟2.0∥次,一日二次。3天后患者出现意识模糊、嗜睡,遂停用,转入我院。既往无癫痫及其它神经系统疾病史。体检:T38.5℃,P81次/分,BP150/85mmHg,R20次/分;
出处 《临床肾脏病杂志》 2007年第5期239-239,共1页 Journal Of Clinical Nephrology
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参考文献2

  • 1Sugimoto M, Uchida I, Mashino T, et al. Evidence for the involvement of GABA (A) recaptor blockade in convulsions induced by cephalosporins. Neuro pharmacyology, 2003, 45: 304-314.
  • 2曾红兵,徐桂华,孙世澜.血液透析患者头孢类抗生素脑病[J].临床肾脏病杂志,2005,5(4):164-166. 被引量:22

二级参考文献6

  • 1Brink B, Kimland E, Von Euler M. An unusual case of a side effect. Cefotaxime-induced confusion in a patient with renal failure Lakartidningen, 2003, 100:2370-2371.
  • 2Fishbain JT, Monahan TP, Canonico MM. Cerebral manifestations of cefepime toxicity in a dialysis patient. Neurology, 2000,55:1756-1757.
  • 3Herishanu YO, Zlomik M, Mostoslavsky M ,et al. Cefuroximeinduced encephalopathy. Neurology, 1998, 50:1873-1875.
  • 4Martinez-Rodriguez JE,Barriga FJ, Santamaria J, et al. Nonconvulsive status epilepticus associated with cephalosporins in patients with renal failure. AmJ Med , 2001,111:115-119.
  • 5Ferrara N, Abete P, Giordano M, et al. Neurotoxicity induced by Cefepime in a very old hemodialysis patient. Clin Nephrol,2003, 59: 388-390.
  • 6Sugimoto M, Uchida I, Mashimo T, et al. Evidence for the involvement of GABA(A) receptor blockade in convulsions induced by cephalosporins. Neuropharmacology, 2003 ,45:304-314.

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