肿瘤标志物在前列腺癌组织中的分布

Distribution of Tumor Markers (PAP, PSA and HNK-1 ) in Prostatic Cancer

本研究采用抗PKP、PSK及KNK－1单克隆抗体对68例前列腺癌患者的石蜡组织切片进行免疫组织化学（ABC）染色，观察免疫染色反应后阳性癌细胞的比率和染色强度及其与肿瘤分化度之间的关系。结果表明：抗PAP、PSA及HNK－1单克隆抗体免疫组化反应的阳性率分别为57．3％、72％及引％，对三种单克隆免疫组化反应的总阳性率为97．1％。抗PAP免疫组化反应与肿瘤分化度无关；而抗PSA及HNK－1免疫组化反应与肿瘤分化呈正相关。

Sixty-eight paraffin-embedded tissue sections were immunohistochemically stained by ABC method using anti-PAP.anti-PSA and anti-HNK-1 monoclonal antibodies. The ratio of positively stained cancer cells and the intensity of the immunostaining were observed and their relationship with the histological differentiation of prostate cancer was revealed. The results showed that the positive rate of antiPAP.and-PSA and anti-HNK-1 immunohistochemical reaction was 57. 3. 72 and 91percent, respectively, with the total positive rate being 97. 1 percent. The anti-PAP immunohistochemical reaction was not related to the differentiation of the prostate cancer, while the anti-PSA and anti-HNK-1 immunohistochemicasl reaction paralleled to the tumorous differentiation.