大剂量醛氢叶酸合并氟脲嘧啶为主联合方案与FAM方案治疗晚期胃癌近期疗效分析

Analysis of the short-term efficacy about high-dose leucovorin and 5-Fu based combination compared with FAM regime in treating advanced gastric carcinoma

用大剂量醛氢叶酸合并氟脲嘧咬为主联合方案与FAM方案分别治疗晚期胃癌30例，有效率分别为39．28％和43．33％，完全缓解率分别为10．71％和3．33％，P均＞0．05，两组消化道反应和骨髓抑制相似，FAM有2伊1出现心电图异常，而大剂量醛氢叶酸组无心电图异常，心脏毒性低于FAM组，我们认为大剂量醛氢叶酸合并氟脲嘧啶是治疗晚期胃癌的有效方案，尤其适用于有心脏病患者。

Both 30 patients of advanced gastric carcinoma were treated to using high-dose leucovorin and 5-Fu based regimen and FAM regimen. The overall response rates were 39. 28% and 43. 33% respectively. The complete response rates were 10. 71 %and 3. 33% respectively. P>0. 05. The gastrointestinal tract reaction and myelosuppression were similar in both group. ECG abnormality was seen in 2 patients in FAM group, but none in high-dose leucovorin group. Cardiac toxicities were less frequency in high-dose leucovorin group than in FAM group. The trial suggests that high-dose leucovorin and 5-Fu based regimen is effective for advanced gastric carcinoma and is especially suitable for patients with cardiac disorders.