两种肺表面活性剂药效的实验比较

COMPARATIVE STUDY ON THE EFFICACY OF A PULMONARY SURFACTANT

为确定从小牛肺提取的肺表面活性物质制剂开塞肺的药效及其剂量范围，对通过肺灌洗造成的豚鼠肺表面活性物质缺乏模型进行了实验研究，同时与德国同类制剂（Ａｌｖｅｏｆａｃｔ）作了对比。两制剂各剂量组用药后，肺顺应性及气体交换均显著改善（Ｐ＜０．０１），并呈现剂量依赖性。证明开塞肺对继发性肺表面活性物质缺乏性疾病是一有效制剂，３５ｍｇ／ｋｇ剂量已有显著治疗作用，高剂量效果优于低剂量，最适剂量约为１００ｍｇ／ｋｇ，与国外制剂无显著性差异。

The study was conducted in guinea pigs with surfactant deficiency created by lung lavage.Calsurf(a pulmonary surfactant extracted from calf lung)were distributed to the animals in doses of 35,105,and 175 mg/kg and Alveofact was used in the same doses in control groups.Dose dependent improvement in lung compliance and gas exchange were observed in both treated and control groups indicating that Calsurf is as effective as Alveofact in treatment of pulmonary surfactant deficiency with an appropriate dose of about 100 mg/kg.