乌鲁木齐地区干眼危险因素的病例对照研究

A investigation on the risk factors of dry eye in Urumqi area

目的:探讨干眼发病的危险因素。方法:采用以医院为基础的病例对照研究方法以统一的调查表及调查方式对134例干眼及268例对照进行面对面问卷调查,采用多因素条件logistic回归模型分析。结果:多因素条件logistic回归分析显示以下因素是与干眼相关的危险因素:翼状胬肉(P<0.001,OR3.982,CI1.982～2.532),糖尿病(P<0.001,OR3.144,CI1.788～5.529),滴眼液(P<0.001,OR1.890,CI1.338～2.668),使用视频终端(P<0.05,OR1.737,CI1.192～2.5321.192～2.532),而服用阿斯匹林、多种维生素,甲状腺疾病、高血压、过敏性疾病、青光眼、眼部手术、吸烟史及屈光不正病史等与干眼无相关性。结论:糖尿病、翼状胬肉、长期使用滴眼液和视频终端这些因素可能是新疆与干眼相关的危险因素。

Objective： To investigate the risk factors of dry eye in Urumqi area. Methods： A hospitol based case control study was conducted , including one huandred and thirty-nine cases of dry eye and 268 cases of controls. All cases were face to face interviewered with a uniformed questionnaire. Conditional logistic regression model was used for univariable and multivariate analysis. Results： The following factors were associated with dry eye in a multivariate conditional logistic regression analysis： pterygium （P 〈0. 001,OR 3.982,CI 1. 982-2. 532） , diabete （P 〈0. 001, OR 3. 144,CI 1. 788-5. 529）, the use of eye drop （P〈0. 001,OR 1. 890,CI 1. 338-2. 668） and video display terminal （VDT） （P 〈0.05,OR 1. 737,CI 1. 192-2. 532）; Nonsignificant variables included： history of hypertension, allergies, eye surgery, refractive error, glaucoma, thyroid disease, smoking, use of multivitamin, aspirin et al. Conclusions： Several factors, such as pterygium, diabete, the use of eye drop and VDT may be dangerous elements of dry eye.