138例乳腺癌临床预后因素分析

The anlysis of clinical prognostic factor in breast cancer patients

目的分析138例乳腺癌临床病理因素的预后价值。方法收集自1996年5月1日～1997年12月31日本科收治的、经病理证实的138例乳腺癌患者的病史资料,分析年龄、肿瘤大小、肿瘤组织学分级、激素受体状态、腋淋巴结转移情况及绝经情况对乳腺癌预后的影响。结果据SPSS15.0软件多元回归分析患者10年总生存率与肿瘤大小、肿瘤组织学分级、腋淋巴结转移及PR均显著相关。而与ER、绝经情况和年龄无明显关系;患者10年远处转移发生率、10年局部复发率与腋淋巴结转移、肿瘤大小、组织学分级显著相关。结论肿瘤大小、肿瘤组织学分级、PR及腋淋巴结转移情况时乳腺癌是有价值的、独立的预后因素。没有证据证明年龄及绝经情况是有意义的预后因素。

Objective To investigate the value of clinical prognostic fators in 138 patients with breast cancer. Methods The analysis was performed in 138 cases of the breast cancer who had pathologic proot and treated from May 1,1996 to Dec 31,1997. The correlation of age,tumor size, histologic grade of the tumors, axillary lymph node involvement, steroiol hormont receptor statns, menopausal status with prognosis of breast cancer was evaluated. Results SPSS 15.0 analysis revealed that 10-year overall survival rate of this group was significantly associated with tumor size, histologic grade of the tumors,axillary lymph node involvement, progesterone receptor status, And oestrogen receptor status,age,menopause status had no significant independent prognostic value. In addition,the 10-year local relapse rate and the rate of 10-year distant metastases in this group was associated with axillary lymph node involvement, tumor size,histologic grade. Conclusion Our data demonstrat that tumor size,histologic grade,progesterone receptor status and axillary lymph node involvement are significant independent indicators of prognosis in breast cancer respectively, and it is not demonstrated that age oestrogen receptor and menopausal status were significant prognostic factors.