人组织激肽释放酶的神经保护作用

Neuroprotective Effects of Human Tissue Kallikrein

大量临床和实验研究提示，人组织激肽释放酶（HTK）具有神经保护作用，如扩张脑动脉、促进缺血脑内新血管形成、促进神经胶质细胞迁移、抑制细胞凋亡、减少炎症细胞浸润等。基因敲除和转基因模型的建立进一步扩大了对HTK研究的深度和广度，为缺血性脑血管病的治疗和新药开发提供了广阔的前景。

A large number of clinical and experimental studies have suggested that the human tissue kallikrein （HTK） has the effects of neuroprotection, such as dilating brain arteries, enhancing neovascularization in ischemic brain, promoting neuroglial cell migration, inhibiting apoptosis, and reducing inflammatory cell infiltration, etc. The establishment of gene knockout and transgenic animal models has further extended the depth and scope of the HTK study, which provides a broad prospect for the treatment of ischemic cerebrovascular disease and dexelopment of new medications.