卡巴肼的合成研究

Study off Synthesis of Carbohydrazide

用"绿色化学品"碳酸二甲酯与合水肼反应合成卡巴肼,该法不使用传统路线的剧毒光气,是一条环境友好的合成路线,反应条件温和,反应时间短,产率高,操作简便,易于实现工业化,收率可达85.2%。

Carbohydrazide is easily synthesized by reason of nontoxic “green” reagent, dimethylcarbonate with hydrazine hydiate. This eeo - friendly, straegy effciently avoids using ofextremely toxic phosgene, and has feabures of mild coodtion, short reaction pe- riod,andsimple work - up procedure, easy to produce in factory. The yield is 85.2% .