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颈椎后纵韧带骨化:钙化及骨化灶表面组织病理学发现 被引量:1

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摘要 本文作者对颈椎骨化的后纵韧带,特别是钙化及骨化灶表面,进行了组织学及免疫组织化学研究。作者对31例患者整个后纵韧带骨化灶标本进行一系列检测,包括HE染色,Ⅰ、Ⅱ型胶原、血管内皮生长因子(VEGF)、转移生长因子-β(TGF—β)、骨形态发生蛋白-2(BMP-2)免疫组化,及TUNEL法检测细胞凋亡。结果在韧带表面与韧带深层间软骨内骨化较明显,
出处 《脊柱外科杂志》 2007年第4期254-255,共2页 Journal of Spinal Surgery
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  • 1董军,袁文,王新伟,徐盛明,汤俊君,张颖.颈椎后纵韧带骨化成纤维细胞的培养及其生物学特性[J].脊柱外科杂志,2007,5(2):109-112. 被引量:7
  • 2Inamasu J, Guiot BH, Sachs DC. Ossification of the posterior longi- tudinal ligament : an update on its biology, epidemiology, and natural history[J]. Neurosurgery, 2006, 58(6) : 1027-1039.
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  • 6邹仲之.组织学与胚胎学[M].北京:人民卫生出版社,2006.
  • 7Ishida Y, Kawai S. Characterization of cultured cells derived from ossification of the posterior longitudinal ligament of the spine [J]. Bone, 1993, 14(2): 85-91.
  • 8Kondo S, Onari K, Watanabe K, et al. Hypertrophy of the pos- terior longitudinal ligament is a prodromal condition to ossifica- tion: a cervical myelopathy case report [ J ]. Spine (Phila Pa 1976), 2001,26(1) :110-114.
  • 9Yokosuka K, Park JS, ,limbo K, et al. Immunohistochemical demonstration of advanced glycation end products and the effects of advanced glycation end products in ossified ligament tissues in vitro[ J]. Spine (Phila Pa 1976), 2007,32( 11 ) : E337-339.
  • 10Wennberg C, Hessle L, Lundberg P, et al. Functional charactenza- tion of osteoblasts and osteoclasts from alkaline phosphatase knock- out mice[J]. J Bone Miner Res, 2000, 15(10) : 1879-1888.

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