采用全麻的非颅脑手术控制颅内压对患者术后认知功能恢复的影响

Cognitive function recovery of control intracranial pressure under general anaesthesia in patients underwent non-craniocerebral operations

目的:探讨控制颅内压(ICP)与患者术后复苏及手术后认知功能恢复的关系。方法:随机将选择全麻的非颅脑手术患者90例分为甲组(控制颅内压)及乙组(不控制颅内压),两组麻醉方法及用药相同,甲组采用冰帽联合肌内注射氯丙嗪(0.5 mg/kg)控制ICP,在麻醉诱导前及手术后1,3,6,24 h应用Mini-Mental State(MMS)测试方法评定其认知功能。结果:术后1 h,甲组MMS值为(27.3±1.5),乙组为(21.1±1.5)(P<0.05);术后3,6,24 h,两组比较无显著性差异(P>0.05)。结论:控制ICP可加速全麻患者术后认知功能的恢复。

Objective： To discuss the relationship of control intracranial pressure（ICP） with post operative resuscitation and cognitive functional recovery.Methods： Ninety patients underwent non-craniocerebral operations under general anaesthesia were divided randomly into group A（control intracranial pressure） and group B（no control intracranial pressure）.Method of anaesthesia and drugs were the same in two groups.Patients in group A were subjected to ice cap and chlorderazin 0.5mg/kg injected intramuscularly for controlling ICP.Cognitive function was tested one hour before anesthesia induction and 1,3,6,24 hrs post operation by Mini-Mental State（MMS）.Results： MMS score in group A was（27.3±1.5）and in group B was（21.1±1.5）post operation 1 hour（P〈0.05）;but no differences 3,6,24 hrs post operation between two groups.Conclusion： Control ICP could accelerate post operative cognition function recovery.