氟比洛芬酯超前镇痛在妇科腹腔镜手术的应用

Pre-empty Analgesic Effect of Flurbiprofen axetil in Gynecological Patients Undergoing Laparoscopic Surgery

目的:研究氟比洛芬酯超前镇痛在妇科腹腔镜手术中的应用。方法:60例ASAⅠ～Ⅱ级择期行妇科手术的患者,随机分为三组,每组20例。对照组(C组)麻醉诱导前和术毕患者拔管清醒即刻静脉缓慢注射脂肪乳5mL;超前镇痛组(P组)麻醉诱导前静脉缓慢注射氟比洛芬酯5mL,术毕患者拔管清醒即刻静脉缓慢注射脂肪乳5mL;常规镇痛组(R组)麻醉诱导前静脉缓慢注射脂肪乳5mL,术毕患者拔管清醒即刻静脉缓慢注射氟比洛芬酯5mL。分别记录拔管清醒即刻、1、2、4、6、12、24h的视觉模拟评分法(VAS)的评分;记录24小时追加镇痛药情况;并统计24h内不良反应。结果:术后P组1、2、4、6、12h的VAS评分明显低于C组同时点VAS评分(P<0.05);而P组1、2、4、6h的VAS评分明显低于R组同时点VAS评分(P<0.05)。结论:氟比洛芬酯可安全地用于妇科腹腔镜手术镇痛,而使用超前镇痛可提供更好的术后镇痛效果。

Objective： To evaluate the efficacy and safety of flurbiprofen axetil in gynecological patients undergoing laparoscopic surgery. Methods： 60 ASA Ⅰor Ⅱ gynecological patients scheduled for elective laparoscopic surgery were randomly allocated into three groups （n=20 each）. Group C （control）： fat milk 5 mL were given both before induction and after recovery. Group P （pre-empty） ： flurbiprofen axetil 5mL was given before induction and fat milk 5 mL was given after recovery. Group R （regular） ： fat milk 5mL was given before induction and flurbiprofen axetil 5 mL was given after recovery. Additional dosages of analgesics and side effect within 24 hours, VAS at 0, 1, 2, 4, 6, 12, 24 hr were recorded. Results： In group P, the VAS was lower than group C （P 〈 0.05） at all time point, and lower than group R （P 〈 0.05） at the former time point （0, 1, 2, 4, 6 h）. Conclusion： Pre-empty analgesic with flurbiprofen axetil could provide satisfying analgesic effect in gynecological patients undergoing laparoscopic surgery.