摘要
目的探讨 PET/CT 和 CT 大体靶区(GTV)在肺癌患者之间、观察者之间、资料来源之间的差异以及 GTV 亚组之间的统计分析方法。方法通过检索 PUBMED 和 EMBASE,得到在肺癌患者中用 PET/CT 勾画 GTV 的文献,针对 GTV 进行统计分析。结果在2006年3月的检索中,共得到4篇相关文献。4项研究间的统计分析表明,虽然4项研究的 GTV_(CT)差异有统计学意义(F=9.43,P<0.01),但 GTV_(PET/CT)间差异无统计学意义(F=1.83,P=0.149)。对 Steenbakkers 等的研究分析表明,GTV_(PET/CT)和 GTV_(CT)的绝对差值在观察者之间(F=3.93,P<0.01),GTV_(PET/CT)和 GTV_(CT)之间(F=29.31,P<0.01)的差异均有统计学意义。GTV_(PET/CT)和 GTV_(CT)的绝对差值和一致性分别与"相对金标准"有较好的相关性(偏相关系数分别为0.384和0.506,P 均<0.01)。结论 GTV_(PET/CT)和 GTV_(CT)在患者、观察者、资料来源之间差异有统计学意义。PET/CT 可以改变常规放疗计划,减少观察者勾画靶区的差异。另外,硬件融合图像 GTV 的离散程度比软件融合图像小,其差异有统计学意义。
Objective The aim of this study was to analyze the diversity of gross target volume （GTV） PET/CT and GTVCT in different patients, observers and studies, and to find a statistical method to identify the discrepancy among subsets of GTV. Methods The articles in PUBMED and EMBASE that defined target volume based on PET/CT images among lung cancer patients were reviewed and analyzed statistically. Results Four relative papers were found in the searches （ till March 2006）. The statistical analysis of the 4 studies had shown that significant difference of GTVcT existed among studies （ F = 9.43, P 〈 0.01 ）, but GTVPET/CT remitted （F = 1.83 ,P = 0. 149）. In the data of Steenbakkers et al, significant differences existed among observers （ F = 3.93, P 〈 0.01 ） in both GTVPET/CT and GTVCT （ F = 29.31 , P 〈 0.01 ）. Absolute diversity and concordance were better with ＂ relative golden standard＂ （ partial correlations were 0. 384 and 0. 506, respectively, both P 〈 0.01 ）. Conclusions There was significant difference of GTVPET/CT and GTVCT among patients, observers or studies. PET/CT could significantly change the radiotherapy planning, reduce the variance among observers. In addition, the GTV on hardware fusion images, compared with software fusion, had a narrow range with a significant statistical difference.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2007年第5期300-302,共3页
Chinese Journal of Nuclear Medicine
