胃肠道间质瘤与原癌基因c-kit的研究进展

Research advance of gastrointestinal stromal tumors and c-kit gene

胃肠道间质瘤起源于胃肠道间质细胞,原癌基因c-kit突变是其主要发病机制之一。c-kit突变形式多样,其突变类型与胃肠道间质瘤的生物学特性及预后相关。伊马替尼通过阻滞c-kit受体从而抑制肿瘤生长。

Gastrointestinal stromal tumors（GIST） are thought to originate from the interstitial cells of cajal. Mutation of c-kit gene indicate an important role in GIST, which is related with biology behavior and prognosis of GIST. Imatinib mesylate inhibits the receptor of c-kit to restrain the tumor growth.