摘要
1997年发现的内吗啡肽(EM)是μ-阿片受体(MOR)的高亲和力、高选择性的内源性配体。EM与MOR高亲和力结合后,通过激活G蛋白,抑制腺苷酸环化酶引起离子通道的变化,从而广泛参与痛觉调制、摄食行为、感知、心血管、消化和免疫功能的调节。此文重点就内吗啡肽在胃肠动力方面的研究进展作一综述。
Endomorphins（EM） discovered in 1997 is an endogenous ligand for the μ-opioid receptor（MOR）, which bind to MOR with high affinity and selectivity. Binding with MOR, endomorphin results in changes of ion channel by activating G-protein and inhibiting adenylcyclase, endomorphin is involved in functional modulation of antinociception, feeding behavior, sensation and perception, cardiovascular activity, gastrointestinal motility and immune system. This article reviews the research progress of endomorphins on the gastrointestinal motility.
出处
《国际消化病杂志》
CAS
2007年第5期345-347,共3页
International Journal of Digestive Diseases
基金
国家自然科学基金资助项目(30670955)
关键词
内吗啡肽
胃肠动力
Μ-阿片受体
纳络酮
Endomorphins
Gastrointestinal motility
μ-opioid receptors Naloxone
