DLG5与炎症性肠病的研究进展

Investigation progression of relationship between DLG5 and inflammatory bowel disease

炎症性肠病(IBD)是一种多基因疾病,具有遗传易感性,主要表现为家族聚集倾向和单卵双生共患率显著增高[1]。近年来,随着人类基因组和多基因疾病研究方法的进展,相继发现多个IBD的基因易感位点。其中DLG5是近年来研究热点之一的易感基因,争议也颇多。

Inflammaory bowel disease（IBD） is a polygenic disease with genetic susceptibility for consistent familial clustering and increased concordance in monozygotic twins. Recently, because of the progression of human genome project and approaches to polygenic diseases, we have found several IBD-associated susceptibility loci. DLGS, one of the IBD-assciated susceptibility gene, is being heatedly discussed. It is valuable to the better diagnosis and therapy of IBD.