近视LASEK术后Haze发生的相关因素分析

Features associated with occurrence of subepithelial corneal haze after laser subepithelial keratomileusis

目的 探讨准分子激光上皮下角膜磨镶（LASEK）手术后角膜上皮下雾状混浊（Haze）发生的相关因素。方法 回顾分析我中心202眼LASEK术前的有关因素（眼别、性别、年龄、眼压值、等效球镜度数、中央角膜厚度、隐形眼镜配戴史）,检查结果量化后进行Logistic回归分析。结果 随访时间半年到1年（平均0.9年）,随访结果示6个月时1级以上（包括1级）Haze发生率为10%,等效球镜度数与Haze发生相关。屈光度数越高,发生率越高。眼别、性别、年龄、眼压值、中央角膜厚度、是否有隐形眼镜配戴史1年以上等均未显示与Haze发生相关。结论 屈光度数高近视者易于Haze的形成。

Objective To explore factors which lead to occurrence of subepithelial corneal haze after laser subepithelial keratomileusis（LASEK）.Methods LASEK was performed on 202 eyes of 106 patients between Jan, 2004 and Jun,2004 in our hospital. The patient data were evaluated retrospectively included left eye or right eye, sex, age, preoperative intraocular press, preoperative spherical equivalent refraction （SE）, preoperative central corneal thickness and history of corneal contact lens. The data was analyzed using Logistic Regression method. Results Follow-up results （with a mean follow-up time of 1.2 years ranging from half year to 2 year） showed that the occurrence rate of Haze was 10%. SE was associated with the occurrence of Haze. Conclusion Severe spherical equivalent refraction is associated with a higher occurrence rate of Haze in myopic patients.