期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

组织多普勒成像技术评价阿托伐他汀对冠心病患者左室舒张功能的影响

下载PDF
导出
摘要 目的探讨应用组织多普勒成像(TDI)技术研究阿托伐他汀对冠心病患者左室舒张功能的影响。方法63例冠心病患者随机分为治疗组和对照组,对照组给予常规治疗,治疗组在常规治疗基础上给予阿托伐他汀10mg,疗程6个月。应用TDI技术测量两组治疗前后左室壁18个节段舒张早期峰值速度(VE)、舒张晚期峰值速度(VA)和二者比值(VE/VA),并计算12个节段心肌平均舒张早期峰值速度(VE)、舒张晚期峰值速度(VA)和(VE/VA),同时检测血脂水平。结果①治疗组后室壁所有节段中,有9个节段的VE和VE/VA显著升高(P<0.05),而对照组治疗前后无显著差异。②治疗组较治疗前和对照组显著升高(P<0.05)。③治疗后,两组患者胆固醇、甘油三酯和低密度脂蛋白胆固醇水平都不同程度降低(P<0.05)。结论阿托伐他汀可改善冠心病患者的左室舒张功能,而且并不完全依赖于其调脂的能力。
作者 李继福 冯民 郄良毅 黎莉 孔光明 李贵双
机构地区 教育部和卫生部心血管重构和功能研究重点实验室山东大学齐鲁医院心内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2007年第20期2004-2006,共3页 Chinese Journal of Gerontology
关键词 组织多普勒成像(TDI) 阿托伐他汀 左心室 舒张功能
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献10

  • 1Fujimoto S,Oki T,Tabata T,et a1.Novel approach to the quantitation of regional left ventricular systolic and diastolic function using tissue Doppler imaging to create a myocardial velocity profile and gradient[J].Circulation,2003; 67(5):416-22.
  • 2叶平.重视他汀类药物在冠心病整体防治中的作用[J].中华医学杂志,2005,85(40):2812-2814. 被引量：7
  • 3方圻,王钟林,宁田海,邵耕,陈在嘉,陆宗良,李健斋,林传骧,周北凡,诸骏仁,诸永康,陶萍,陶寿淇,龚兰生,顾复生,游凯,戴玉华.血脂异常防治建议[J].中华心血管病杂志,1997,25(3):169-175. 被引量：3067
  • 4Garcia-Fernandez MA,Azevedo J,Moreno M,et al.Regional diastolic function in ischaemic heart disease using pulsedwave Doppler tissue imaging[J].Eur Heart,1999; 20(7):476-7.
  • 5Govind S,Saha S,Brodin LA,et al.Impaired myocardial functional reserve in hypertension and diabetes mellitus without coronary artery disease:searching for the possible link with congestive hear failure in the Myocardial Doppler in Diabetes(MYDID) Study Ⅱ[J].Am Hypertens,2006; 19(8):851-7.
  • 6Bountioukos M,RizzelloV,Krenning BJ,et al.Effect of atorvastatin on myocardial contractile reserve assessed by tissue Doppler imaging in moderately hypercholesterolemic patients without heart disease[J].Am Cardiol,2003; 92(5):613-6.
  • 7Kuryata OV,Yegorova YV.The influence of low-dose atorvastatin on lipid levels and endothelial vascular function in patients with significant coronary artery stenosis[J].Kardiol Pol,2006;64(1):44-8.
  • 8Atalar E,Ozamen F,Hazneedaroglu I,et al.Effects of short-term atorvastatin treatment on global fibrinolytic capacity,and sL-selection and sFas levels in hyperlipidemic patients with coronary artery disease[J].Int Cardiol,2002;84(2-3):227-31.
  • 9Sata M,Nishimatsu H,Suzuki E,et a1.Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia[J].FASE,2001;15(13):2530-2.
  • 10Pourati I,Kimmelstiel C,Rand W,et al.Statin use is associated with enhanced collateralization of severely diseased coronary arteries[J].Am Heart,2003;146(5):876-81.

二级参考文献6

  • 1Ray JG, Gong Y, Sykora K, et al. Statin use and survival outcomes in elderly patients with heart failure. Arch Intern Med,2005,165:62-67.
  • 2Chiu JH, Abdelhadi RH, Chung NK, et al. Effect of statin therapy on risk of ventricular arrhythmia among patients with coronary artery disease and an implantable cardioverter- defibrillator. Am J Cardiol, 2005,95:490-491.
  • 3Young XY, Jabbour S, Goldberg R, et al. Usefulness of statin drugs in protecting against atrial fibrillation in patients with coronary artery disease. Am J Cardiol,2003,92:1379-1383.
  • 4Okazaki S, Yokoyama T, Miyauchi K, et al. Early statin treatment in patients with acute coronary syndrome: demonstration of the beneficial effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: the ESTABLISH Study. Circulation,2004,110:1061-1068.
  • 5Salam AM. Intensive lipid-lowering therapy in coronary artery disease: implications of the REVERSAL and PROVE-IT trials. Expert Opin Investig Drugs,2004,13:707-713.
  • 6Mulukutla SR, Marroquin OC, Smith C, et al. Effect of statin therapy prior to elective percutaneous coronary intervention on frequency of periprocedural myocardial injury. Am J Cardiol, 2004, 94:1363-1366.

共引文献3071

中国老年学杂志
2007年 第20期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部