摘要
每年流行性感冒(流感)导致全球超过2万人死亡,10万人住院治疗。在亚热带地区,流感是导致儿童住院的一个重要原因。流感病毒分为甲、乙、丙三型,其中甲型最易发生变异而产生新的变种,引起世界性流感大流行。根据历史上已发生的三次全球性流感大流行的分析,流感病毒一般每三、四十年会发生一次较大变异,每次变异都会引发全球性的流感大流行。其中1918年至1920年爆发的“西班牙流感”至少使2000万人丧生。
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2007年第11期831-834,共4页
Chinese Journal of Pediatrics
参考文献42
-
1Chiu SS, Lau YL, Chan KH, et al. Influenza-related hospitalizations among children in Hong Kong. N Engl J Med, 2002,347:2097-2103.
-
2Lewis DB. Avian flu to human influenza. Annu Rev Med,2006, 57 : 139-154.
-
3Steinhauer DA. Role of hemagglutinin cleavage for the pathogenicity of influenza virus. Virology, 1999,258 : 1-20.
-
4Matrosovich MN, Matrosovich TY, Gray T,et al. Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. J Virol,2004,78 : 12665-12667.
-
5Hilleman MR. Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control. Vaccine ,2002,20 : 3068- 3087.
-
6Kaye D, Pringle CR. Avian influenza viruses and their implication for human health. Clin Infect Dis,2005,40:108-112.
-
7Fouchier RA, Munster V, Wallensten A, et al. Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J Virol,2005 ,79 :2814-2822.
-
8Zambon MC. The pathogenesis of influenza in humans. Rev Med Virol, 2001,11-227-241.
-
9Webby RJ, Webster RG. Are we ready for pandemic influenza? Science, 2003,302 : 1519-1522.
-
10Diebold SS, Kaisho T, Hemmi H,et al. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science, 2004,303 : 1529-1531.
同被引文献48
-
1卢建红,邵卫星,韦栋平,刘秀梵.禽流感病毒感染的宿主免疫应答[J].动物医学进展,2004,25(5):37-40. 被引量:8
-
2Dawood FS,Jain S,Finelli L,et al.Emergence of a novel swine-origin influenza A(H1N1) virus in humans.N Engl J Med,2009,360:2605-2615.
-
3Fraser C,Donnelly CA,Cauchemez S,et al.Pandemic potential of a strain of influenza A(H1N1):early findings.Science,2009,324:1557-1561.
-
4Siren J,Sareneva T,Pirhonen J,et al.Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages.J Gen Virol,2004,85:2357-2364.
-
5Draghi M,Pashine A,Sanjanwala B,et al.NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection.J Immunol,2007,178:2688-2698.
-
6Mao H,Tu W,Qin G,et al.Influenza virus directly infects human natural killer cells and induces cell apoptosis.J Virol,2009,83:9215-9222.
-
7Guo H,Kumar P,Moran TM,et al.The functional impairment of natural killer cells during influenza virus infection.Immunol Cell Biol,2009,87:579-589.
-
8Mao H,Tu W,Liu Y,et al.Inhibition of human natural killer cell activity by influenza virions and hemagghtinin.J Virol,2010,84:4148-4157.
-
9O'Riordan S,Barton M,Yau Y,et al.Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza.CMAJ,182:39-44.
-
10Hancock K,Veguilla V,Lu X,et al.Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus.N Engl J Med,2009,361:1945-1952.
引证文献2
-
1涂文伟,毛华伟,秦刚,郑建,李虹,刘宇隆.甲型H1N1流感大流行的机遇与挑战[J].中华儿科杂志,2010,48(8):561-563.
-
2王慧敏,陈杭薇.细胞因子在流感病毒感染中的免疫调节作用[J].国际呼吸杂志,2011,31(2):116-119. 被引量:4
二级引证文献4
-
1周南南,林文基,唐文辉.血浆B型脑钠肽在急性呼吸道感染合并心衰患者诊断中的意义[J].海南医学院学报,2012,18(5):625-626. 被引量:5
-
2古军恩,陈志坚,宋启宾.B型脑钠肽(BNP)含量变化在心力衰竭发病中的作用及临床意义[J].中国现代药物应用,2013,7(14):93-94. 被引量:8
-
3徐红日,王成祥,王兰,周平安,殷人易,姜良铎,王惠芳.益气清瘟解毒合剂所含益气法中药抗流感免疫炎性损伤的机制[J].中国中药杂志,2014,39(20):4020-4026. 被引量:16
-
4王学文,刘佐民,王劲松,李永清.复方中药对流感病毒A/PR/8/34(H1N1)感染小鼠淋巴细胞功能和细胞因子的影响[J].实验动物科学,2020,37(6):30-36. 被引量:2
-
1王奕功,张琳.运气学说预测全球性流感大流行初探[J].湖南中医杂志,1999,15(4):50-50. 被引量:7
-
2孙利民.气候变化与SARS发病[J].中医杂志,2004,45(3):236-236.
-
3邱婷,洪佳旭,徐建江.单纯疱疹病毒性角膜炎发病机制的研究新进展[J].中国眼耳鼻喉科杂志,2008,8(3):198-199. 被引量:6
-
4李海英,张旭珍.中医专家解析甲型H1N1流感——专访上海市甲型H1N1流感中医药防控专家防治组组长吴银根教授[J].中医药文化,2009,4(3):8-10. 被引量:1
-
5阿魏根含有抗H1N1甲型流感病毒成分[J].广东药学院学报,2009,25(5):537-537.
-
6蔡英,王晶桐.幽门螺杆菌相关慢性炎症和免疫因子在胃癌中的研究进展[J].中国综合临床,2009,25(3):331-333. 被引量:7
-
7邓铁涛.中医与未来医学[J].中医药通报,2005,4(2):1-3. 被引量:13
-
8中国军事医学科学院和北京地坛医院研究证实 抗甲型H1N1流感病毒:中药连花清瘟胶囊取得重大突破[J].中国处方药,2009,8(9):41-41. 被引量:10
-
9张小磊,万昀,苗明三.溶血磷脂酸与短暂性脑缺血及中药的调节作用[J].中医学报,2010,25(1):85-88. 被引量:3
-
10赵英凱,崔蒙.应对可能暴发的(禽)流感大流行的中医潜在优势分析[J].中国中医药信息杂志,2006,13(1):2-4.