烟碱乙酰胆碱受体及其激动剂的研究进展

The recent advances of the nicotinic acetylcholine receptor and its agonists

烟碱乙酰胆碱受体是离子门控通道型受体,主要分布于神经节细胞膜和骨骼肌细胞膜上。炯碱乙酰胆碱受体激动剂作用于其受体,在神经兴奋性方面发挥着重要的作用。本文对哺乳动物及昆虫烟碱乙酰胆碱受体结构及其作用的研究进行了总结,特别是对烟碱乙酰胆碱受体激动剂作用于哺乳动物及昆虫烟碱乙酰胆碱受体的选择性机理进行了概括,为开发高效、安全的杀虫剂提供了参考。

Nicotinic acetylcholine receptor （nAChR） is a ligand-gated ion channel, it is mainly distributed in ganglia and skeletal cell membranes. The nAChR agonists bind on the nAChR which play an important role in neural excitability. The structures and functions of the mammalian and insect nAChR are summarized in this paper, especially, depicting the reason of nAChR agonists selectivity for the insect versus mammalian nAChR, which may provide a reference for exploring the safe and selective insecticides.