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肝纤维化逆转过程中肝细胞再生机制的研究 被引量：2

The mechanism of hepatocyte regeneration during regression of hepatic fibrosis
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摘要 肝细胞再生是肝纤维化逆转过程中的重要环节,是纤维化的肝脏组织恢复正常结构的前提条件。肝细胞再生与Ⅰ型胶原的降解密切相关,不能降解Ⅰ型胶原就不能进行有效的肝细胞再生,因此,Ⅰ型胶原降解不仅是促进肝细胞再生,而且是肝纤维化逆转过程中有效肝细胞再生的前提条件。然而目前对于Ⅰ型胶原降解如何触发肝细胞再生的具体机制仍不清楚，
作者 张影 张福奎 贾继东 王宝恩
机构地区 首都医科大学附属北京友谊医院肝病中心
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2007年第10期798-800,共3页 Chinese Journal of Hepatology
关键词 肝细胞 再生 胶原Ⅰ型 受体 玻连蛋白 肝细胞生长因子 肝纤维化 Hepatocytes Regeneration Collagen type Ⅰ Receptors, vitronectin Hepatocyte growth factor Fibrosis, liver
分类号 R686 [医药卫生—骨科学]
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参考文献19

  • 1Iwamoto H, Sakai H, Tada S, et al. Induction of apoptosis in rat hepatic stellate cells by disruption of integrin-mediated cell adhesion. J Lab Clin Med, 1999, 134: 83-89.
  • 2Jin B, Alter HJ, Zhang ZC, et al. Reversibility of experimental rabbit liver cirrhosis by portal collagenase administration. Lab Invest, 2005, 85: 992-1002.
  • 3Benyon RC, Arthur MJ. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis, 2001, 21: 373-384.
  • 4Issa R, Zhou X, Trim N, et al. Mutution in collagen-1 that confers resistance to the action of collagenase results in failure of recovery from CCLA-induced liver fibrosis, persistence of activated hepatic stellate cell, and diminished hepatocyto regeneration. FASEB J, 2003, 17: 47-49.
  • 5Pilcher BK, Dumin JA, Sudbeck BD, et al. The activity of collagenase-1 is required for keratinocyte migration on a type Ⅰ collagen matrix. J Cell Biol, 1997, 137: 1445-1457.
  • 6Eliceiri BP, Cheresh DA. The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest, 1999, 103: 1227-1230.
  • 7Iimuro Y, Nishio T, Morimoto T, et al. Delivery of matrix Metalloproteinase-1 attenuates established liver fibrosis in the rat. Gastroenterology, 2003, 124: 445-458.
  • 8Inoue H, Yokoyama F, Kita Y, et al. Relationship between the proliferative capability of hepatocytes and the intrahepatic expression of hepatocyte growth factor and c-Met in the course of cirrhosis development in rats. Int J Mol Med, 2006, 17: 857-864.
  • 9Huh CG, Factor VM, Sanchez A, et al. Hepatocyte growth factor/cmet signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acadsci U S A, 2004, 101: 4477-4482.
  • 10Phaneuf D, Moscioni AD, LeClair C, et al. Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: demonstration of impaired liver regeneration. DNA Cell Biol ,2004, 23: 592-603.

同被引文献9

  • 1朱英,刘平.肝脏卵圆细胞在二甲基亚硝胺致大鼠肝硬化形成过程中表达的动态变化及其意义[J].国外医学（消化系疾病分册）,2005,25(1):60-63. 被引量：4
  • 2COLEMAN W B,MCCULLOUGH K D,ESCH G L,et al. Evaluation of the differentiation potential of WB-F344 rat liver epithelial stem-like cells in vivo. Differentiation to hepatocytes after transplantation into dipeptidylpeptidase-IV-deficient rat liver[ J]. Am J Pathol, 1997,151 (6) :353-359.
  • 3COUCHIE D, HOLIC N, CHOBERT M N, et al. In vitro differentiation of WB-F344 rat liver epithelial cells into the biliary lineage[J]. Differ- entiation, 2002,69 ( 8 ) :209-215.
  • 4THORGEIRSSON S S, GRISHAM J W. Overview of recent experimental studies on liver stem cells[ J]. Semin Liver Dis,2003,23 (7):303- 312.
  • 5HE Z P,TAN W Q ,TANG Y F. Differentiation of putative hepatic stem ceils derived from adult rats into mature hepatocytes in the presence of epidermal growth factor and hepatocyte growth factor[ J]. Differentia- tion ,2003 ,71 (45) :281-290.
  • 6YOON B I, CHOI Y K, KIM D Y. Differentiation processes of oval cells into hepatocytes: Proposals based on morphological and phenotypical traits in carcinogen treated hamster liver[ J]. J Comp Pathol,2004,131 (1):1-9.
  • 7贾继东,王宝恩.肝纤维化的中医中药治疗[J].中华肝脏病杂志,2001,9(2):120-121. 被引量：79
  • 8皮国涛,潘珂君,孙丽华,买买提艾力.吾布力,张跃新.肝功能衰竭预后影响因素分析[J].新疆医科大学学报,2015,38(11):1403-1406. 被引量：2
  • 9陈耀凯,王宇明,李俊刚,郎松.大鼠肝卵圆细胞的生物学特征[J].世界华人消化杂志,2003,11(4):430-433. 被引量：5

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中华肝脏病杂志
2007年 第10期

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