泮托拉唑治疗创伤弧菌性脓毒症并发上消化道出血12例的疗效观察

Clinical Observation on the Efficacy of Pantoprazole in Treating 12 Cases with Vibrio Vulnificus Sepsis Associated with Upper Gastrointestinal Hemorrhage

目的泮托拉唑为第三代质子泵抑制剂,具有强大的抑制胃酸分泌作用,探讨泮托拉唑对创伤弧菌性脓毒症并上消化道出血的疗效和安全性。方法将12例上消化道出血患者分别用泮托拉唑40 mg静脉滴注,连续5 d,观察临床症状变化。结果12例使用静滴泮托拉唑后,9例3 d内止血为显效,3例有效,有效率为100%。使胃液中的pH值升高至6以上。结论泮托拉唑使用安全有效,是治疗弧菌性脓毒症患者并发上消化道出血的理想药物。

OBJECTIVE Pantoprazole is the third generation of proton pump inhibitor with great effect for inhibiting gastric acid secretion.This article is to study the efficacy and safety of Pantoprazole in treating vibrio vulnificus sepsis associated with upper gastrointestinal hemorrhage.METHODS 12 cases with upper gastrointestinal hemorrhage were treated with Pantoprazole（40 mg） through iv drip for consecutive 5 days,then the changes of clinical symptoms were observed. RESULTS After medication on 12 cases,significant hemostatic effect was observed in 9 cases in 3 days and the drug was also effective in the rest 3 cases,which showed the response rate 100%.The pH value in gastric fluid was enhanced to over 6.CONCLUSION Pantoprazole is safe and effective,and could be the ideal medicine in treating vibrio vulnificus sepsis associated with upper gastrointestinal hemorrhage.