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醛固酮合酶CYP11B2(-344C/T)基因多态性与2型糖尿病肾病的相关性

Relationship between aldosteronesynthase CYP11B2(-344C/T) gene polymorphisms and diabetic nephropathy
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摘要 目的探讨醛固酮合酶CYP11B2(-344C/T)基因多态性与2型糖尿病肾病的关系。方法采用聚合酶链反应-限制性酶切片段长度多态性分析(PCR-RFLP)技术检测95例2型糖尿病患者(其中合并肾病患者32例,未发生肾病63例)和175例健康对照组醛固酮合酶CYP11B2(-344C/T)基因多态性。结果糖尿病肾病组、糖尿病非肾病组和健康对照组两两比较,CYP11B2基因型和等位基因分布均无统计学差异(P>0.05)。与健康对照组比较,糖尿病肾病组和糖尿病非肾病组的血浆醛固酮水平均有极明显增高(P<0.01);糖尿病肾病患者CYP11B2(-344C/T)基因多态性的3种基因型间血浆醛固酮水平比较差异有显著性(P<0.05)。结论醛固酮合酶CYP11B2(-344C/T)基因多态性与2型糖尿病肾病的发生无显著相关性,但可能与血浆醛固酮水平有关。
作者 冯传首 王云英 王培林 崔玉忠
机构地区 青岛大学附属市立医院 青岛大学医学院生物学教研室 山东省临淄区人民医院
出处 《中国心血管杂志》 2007年第5期374-376,共3页 Chinese Journal of Cardiovascular Medicine
关键词 2型糖尿病 糖尿病肾病 醛固酮合酶 基因多态性
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献9

  • 1Kupari M,Hautanen A, Lankinen L, et al. Association between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size, mass, and function [J]. Circulation, 1998,97: 569-575.
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二级参考文献28

  • 1Kupari M, Hautanen A, Lankinen L, et al. Association between human aldosterone synthase (CYPllB2) gene polymorphisms and left ventricular size, mass, and function. Circulation, 1998,97:569-575.
  • 2Delles C, Erdmann J, Jacobi J, et al. Aldosterone synthase (CYP11B2) - 344C/T polymorphism is associated with left ventricular strcture in human arterial hypertension. J Am Coll Cardiol,2001,37 : 878- 884.
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  • 5Tamaki S, Iwai N, Tsujita Y, et al. Genetic polymorphism of CYP11B2 gene and hypertension in Japanese. Hypertension, 1999,33: 266- 270.
  • 6Komiya I, Yamada T, Takara M, et al. Lys(173) Arg and -344T/C variants of CYP11B2 in Japanese patients with low - renin hypertension. Hypertension, 2000, 35 : 699- 703.
  • 7Hautanena A, Lankinen L, Kupari M, et al. Associations between aldosterone synthase gene polymorphism and the adrenocortical function in males. J Intern Med, 1998 ,244:11-18.
  • 8Kupari M,Hautanen A,Lankinen L,et al.Association between human aldosterone synthase(CYP11B2) gene polymorphisms and left ventricular size,mass,and function.Circulation,1998,97 (6):569-575.
  • 9Tamaki S,Iwai N,Tsujita Y,et al.Genetic polymorphism of CYP11B2gene and hypertension in Japanese.Hypertension,1999,33 ( 1 Pt 2 ):266-270.
  • 10Delles C,Erdmann J,Jacobi J,et al.Aldosterone synthase (CYP11B2)-344C/T polymorphism is associated with left ventricular strcture in human arterial hypertension.J Am Coll Cardiol,2001,37 (3):878-884.

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中国心血管杂志
2007年 第5期

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