期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂联素和心血管疾病关系的研究进展 被引量：1

Advances on the relationship study between adiponectin and cardiovascular disease
下载PDF
导出
摘要 探讨脂联素通过对血管内皮细胞及其产生的一氧化氮对血管内皮的功能产生影响,在动脉粥样硬化、冠心病、高血压等心血管疾病方面起到重要的调节作用;血浆脂联素水平低已逐渐认为是心血管疾病的独立危险因素。 Adiponectin has an impact on the endothelial .function by its direct effect on blood vessel endothelial cells and by the nitrogen monoxidum it generates. Adiponectin plays an important modulatory role in the cardiovascular diseases like arterial atherosclerosis, coronary heart disease and hypertension. Low level of plasma adiponectin has gradually been recognized as an independent risk factor for cardiovascular diseases. Further investigations on adiponectin will open up a new area for the basic and clinical research of cardiovascular diseases.
作者 赵志强 田凤石
机构地区 天津医科大学 天津市公安医院心血管内科
出处 《中国心血管杂志》 2007年第5期386-388,共3页 Chinese Journal of Cardiovascular Medicine
关键词 脂联素 血管内皮细胞 心血管病 Adiponectin Endothelial cells Cardiovascular diseases
分类号 R54 [医药卫生—心血管疾病]
  • 相关文献

参考文献20

  • 1Yamauchi T, Kamom J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metablic effects [J]. Nature, 2003, 423: 762-769.
  • 2Chinetti G, Zawadski C, Fruchart J, et al. Expression of adiponectin, receptors in human macrophages and regulation by agonists of the nuclear receptors PPARα, PPARγ, and LXR [J]. Biochem Biophys Res Commun, 2004, 314:151-158.
  • 3Motoshima H, Goldstein B J, Igata M, et al. AMPK and cell proliferation AMPK as a therapeutic target for atherosclerosis and cancer [J]. Physiol, 2006,574: 63-71.
  • 4Ouchi N, Kobayashi H, Kihara S, et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP activated protein kinase and Akt signaling in endothelial cells [J]. J Biol Chem, 2004, 279: 1304-1309.
  • 5Xi W, Satoh H, Kase H, et al. Stimulated Hsp90 binding to eNOS and activa tion of PI3-Akt pathway contribute to globular adiponectin indused NO production: vasorelaxation in response to globular adiponectin [J]. Biochem Biophys Res Commun, 2005, 332:200-205.
  • 6Motoshima H, Wu X D, Mahadev K, et al. APN suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL[J]. Biochem Biophys Res Commun, 2004, 315: 264-271.
  • 7Chan D C, Watts G F, Ng T W, et al. Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipoprotein metabolism [J]. Clin Chem, 2005, 51: 578-585.
  • 8刘金波,邓华聪,葛倩,于冬青.脂联素对脐静脉内皮细胞表达单核细胞趋化蛋白1的影响[J].中华糖尿病杂志（1006-6187）,2005,13(6):463-464. 被引量：3
  • 9Verges B J M, Petit L, Duvillard G, et al. Gambert adiponectin is an important determinant of apoA-I catabolism [J]. Arterioscler Thromb Vasc Biol, 2006, 26: 1364-1369.
  • 10葛庆峰,闫杰.急性心肌梗死患者血清脂联素水平的动态变化[J].临床荟萃,2005,20(11):601-603. 被引量：13

二级参考文献10

  • 1叶任高.内科学[M](第5版)[M].北京:人民卫生出版社,2000.313.
  • 2HOTTA K, FUNAHASHI T, ARITA Y,et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin,in type 2 diabetic patients[J]. Arterioscler Thromb Vasc Biol,2000,20(6):1595-1599.
  • 3KUMADA M, KIHARA S, SUMITSUJI S, et al. Association of hypoadiponectinemia with coronary artery disease in men[J].Arterioscler Thromb Vasc Biol, 2003,23 (1): 85-89.
  • 4OUCHI N, KIHARA S, ARITA Y, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NFkappaB signaling through a c-AMP-dependent pathway[J].Circulation, 2000,102 (11): 1296-1301.
  • 5ISHIKAWA Y, AKASAKA Y, ISHII T, et al. Changes in the distribution pattern of gelatinbinding protein of 28 kDa(adiponectin) in myocardial remodeling after ischaemic injury[J]. Histopathology,2003,42(1):43.
  • 6Arita Y, Kihara S, Ouchi N,et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common post receptor signal in vascular smooth muscle cell. Circulation, 2002,105:2893-2898.
  • 7Chen H, Montagnani M, Funahashi T,et al. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. Biol Chem, 2003,278 : 45021-45026.
  • 8Zietz B, Herfarth H, Paul G,et al. Adiponectin represents an independent cardiovascular risk factor predicting serum HDL-cholesterol levels in type 2 diabetes. FEBS Lett, 2003, 545:103-104.
  • 9Dzielinska Z, Januszewicz A, Wiecek A, et al. Decreased plasma concentration of a novel anti-inflammatory protein-adiponectin-in hypertensive men with coronary artery disease. Thromb Res,2003,110:365-369.
  • 10Bratt J,Belcher J, Vercellotti G M,et al. Effects of anti-rheumatic gold salts on NF-kappa B mobilization and tumour necrosis factoralpha (TNF-αlpha)-induced neutrophil-dependent cytotoxicity for human endothelial cells. Clin Exp Immunol, 2000,120: 79-84.

共引文献13

同被引文献5

引证文献1

二级引证文献1

中国心血管杂志
2007年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部