肝脏胰岛素致敏物质HISS释放的药物动力分析

Medicine Dynamic Analysis of the Release Hepatic Insulin-Sensitizing Substance-HISS

目的:检测一种肝脏胰岛素致敏物质(HISS)反应于胰岛素而释放的药物动力。方法:用快速的胰岛素敏感性试验方法(RIST)比较输入阿托品前、后的RIST指标。其指标由胰岛素输入后为维持正常血糖水平所灌注的葡萄糖量所表示。结果:对照的RIST指标是(223.5±13.4)mg/kg,阿托品后的RIST指标是(71.4±14.7)mg/kg,最大抑制为(66.4±6)%,二者间的葡萄糖输入比率的差异表明:开始于4 min,在头10 min迅速上升,19 min达高峰后迅速下降,34 min左右达基础水平。结论:HISS是一种由胰岛素激活肝脏副交感神经反射释放的激素。在胰岛素输入约4 min后HISS的活性开始,并且其活性时间长于胰岛素活性时间。

Objective： The purpose of this study was to investigate the pharmacodynamics of HISS with respect to its influence on insulin sensitivity in rats. Methods： In this study, rapid insulin sensitivity test （RIST） was used to compare the RIST indexs before and after Atropine administered. The amount of glucose adminis- tered by infusion was used as an index of isulin effectiveness （RIST）. Results： Control RIST index was （223.5 ± 13.4） mg/kg, After atropine administration, The RIST index was （71.4 ± 14.7） mg/kg. The maximum in- hibition was （66.4 ± 6） %. The difference in glucose infusion rate between the control and post - atropine RIST showed an onset at 4 min, a sharp increase in the first 10 min, reached a peak at about 19 min, and rapidly decreased to a baseline level around 34 min after the start of the test, Conclusion： HISS is a hormone released in response to a hepatic parasympathetic reflex activation by insulin. There is a time delay in the onset of HISS action of about 4 rain after administration of insulin and the duration of its action is longer than that of insulin .