CK-MB、cTnI在新生儿缺氧缺血性脑病时的变化及临床意义

Changes and clinical significance of CK-MB and cTnI on HIE

目的:探讨新生儿缺氧缺血性脑病(HIE)时肌酸激酶同工酶(CK-MB)、肌钙蛋白(cTnI)的变化及临床意义。方法:将51例患儿分轻、中、重度组以及60例正常新生儿对照,分别采用连续监测法和ELISA法测定血清中CK-MB和cTnI,并进行统计分析。结果:HIE时血清CK-MB、cTnI随着病情的加重而相应升高,与临床分度相符合。中、重度组较正常对照组明显升高,差异有显著性(P<0.05);轻度组与正常对照组比较差异均无显著性(P>0.05);HIE轻、中、重度组CK-MB、cTnI两两比较差异均有显著性(P<0.05)。结论:CK-MB、cTnI的检测可作为临床分度的指标之一。监测患儿CK-MB、cTnI的变化,能较好地协助临床早期诊断HIE时有无心肌损伤及损伤程度,对判断病情、估计愈后具有重要的临床意义。

Objective To explore the change and the changes of CK-MB and cTnI ,51 cases of HIE significance of CK-MB and cTnI on HIE. Methods According to were divided into three groups： mild group, medium group and heavy group .They were compared with 60 cases of normal newborns and analyzed.Result The concentration of CKMB and cTnI in serum is developed with the condition of disease on HIE ,which is close to clinic with positive relationship. The level of CK-MB and cTnI in medium group and severe group is more than normal＇s obviously and there is a significant difference （P〈0.05）; no significant difference（P〉0.05） between light group and normal group; Conclusion CK-MB and cTnI can be used to divide HIE into different groups. Monitoring them on HIE can easily assist to diagnosis the damage to myocardium in early stage, and there is important clinical significance in diagnosis ,treatment and prognosis.